344347-12-2Relevant academic research and scientific papers
An efficient synthesis of sulfonylhydrazides and sulfonylsemicarbazides by utilizing alumina as a catalyst
Safaei-Ghomi, Javad
, p. 1561 - 1563 (2008/09/16)
Sulfonyl hydrazides and sulfonyl semicarbazides are readily prepared by the reacting of hydrazine derivatives with sulfonyl chlorides in the presence of basic alumina under solvent-free conditions. Reaction of a sulfonyl chloride with t-butylcarbazate, followed by hydrolysis provides the corresponding sulfonyl hydrazides in higher yield and shorter time than previously reported.
Synthesis of sulfanilamido-naphthoquinones as potential antituberculous agents
Osman,Abdalla,Alaib
, p. 68 - 71 (2007/10/02)
p-Aminobenzoic acid, the acid hydrazides of benzoic acid, salicylic acid and isonicotinic acid, and 4,4'-diaminodiphenyl sulfone were condensed with p-aminobenzenesulfonyl chloride to give the corresponding N1-substituted sulfanilamides. These molecules were then treated with 1,4-naphthoquinone to yield 2-substituted-1,4-naphthoquinones. The partition coefficient for the substituted quinones showed, in some cases, high diffusion rates to the organic phase, benzene, from physiological Tyrode's solution. These compounds are effective in low concentration in dioxane against the human sensitive strain of Mycobacterium tuberculosis H37 Rv. Sulfanilamides obtained from p-aminosalicylic acid and thiosemicarbazide failed to react with 1,4-naphthoquinone. These sulfanilamides also showed high activity against the same Mycobacterium.
