344347-82-6Relevant academic research and scientific papers
Asymmetric triple relay catalysis: Enantioselective synthesis of spirocyclic indolines through a one-pot process featuring an asymmetric 6π electrocyclization
Yin, Xiao-Ping,Zeng, Xing-Ping,Liu, Yun-Lin,Liao, Fu-Min,Yu, Jin-Sheng,Zhou, Feng,Zhou, Jian
, p. 13740 - 13745 (2014)
A rare example of a one-pot process that involves asymmetric triple relay catalysis is reported. The key step is an asymmetric [1,5] electrocyclic reaction of functionalized ketimines. The substrates for this process were obtained in situ in a two-step process that involved the hydrogenation of nitroarenes with a Pd/C catalyst to yield aryl amines and their subsequent coupling with isatin derivatives in a Bronsted acid catalyzed ketimine formation reaction. The electrocycli-zation was catalyzed by a bifunctional chiral Bronsted base/ hydrogen bond donor catalyst. The one-pot process gave the desired products in good yields and with excellent enantiose-lectivity.
STEREO- AND ENANTIOSELECTIVE SYNTHESES OF 2,3-DIHYDROINDOLE DERIVATIVES
Spackamp, W. Nico
, p. 211 - 234 (2007/10/02)
2,3-Dihydroindoles (2,3-Indolines) can be obtained in a highly stereoselective fashion through 1,5-electrocyclization of ortho-substituted aminobenzenes.The scope and mechanism of this novel process are discussed and also some applications.In presence of
