10565-14-7

Usage

Uses

Used in Pharmaceutical Industry:
Diethyl (2-nitrophenyl)malonate is used as a synthetic intermediate for the development of various pharmaceuticals. Its ability to modify organic compounds aids in the creation of new chemical entities that can be utilized in the formulation of drugs.
Used in Agrochemical Industry:
In the agrochemical sector, diethyl (2-nitrophenyl)malonate serves as a reagent in the synthesis of agrochemicals, contributing to the development of products that enhance crop protection and yield.
Used in Dye and Pigment Production:
diethyl (2-nitrophenyl)malonate is utilized in the production of dyes and pigments, where its chemical properties contribute to the creation of colorants for various applications, including textiles, plastics, and printing inks.
Used in Medicinal Chemistry Research:
Diethyl (2-nitrophenyl)malonate is employed as a research tool in medicinal chemistry, where it is used to explore the modification of organic compounds and the generation of novel chemical entities with potential therapeutic applications.

Upstream product

• 577-19-5 2-nitrophenyl bromide 
• 105-53-3 diethyl malonate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 88-73-3 2-Chloronitrobenzene 

Downstream Products

• 344347-82-6 diethyl (o-aminophenyl)malonate 
• 88-72-2 1-methyl-2-nitrobenzene 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 
• 14750-19-7 ethyl 2,3-dihydro-3-methyl-2-oxo-1H-indole-3-carboxylate 
• 14750-31-3 1-hydroxy-3-methyl-2-oxo-2,3-dihydro-indole-3-carboxylic acid ethyl ester 
• 71127-36-1 diethyl methyl(2-nitrophenyl)malonate 
• 1396762-90-5 diethyl (S)-2-(2-((benzyloxycarbonyl)amino)-3-phenylpropyl)-2-(2-nitrophenyl)malonate 
• 1396762-95-0 ethyl (3R,5S)-1,5-dibenzyl-3-(2-nitrophenyl)-2-oxopyrrolidine-3-carboxylate 

Relevant academic research and scientific papers

Nucleophilic aromatic substitution using Et3SiH/cat. t-Bu-P4 as a system for nucleophile activation

A novel type of deprotonative arylation of nucleophiles was conducted using Et3SiH/cat. t-Bu-P4 and the powerful SNAr reactions of aryl fluorides were accomplished using alcohols and malonates as nucleophiles. The Royal Society of Ch

Total synthesis of bouchardatine

Two new, efficient and simple routes using Heck-type reaction and intramolecular cyclization were developed for the synthesis of the naturally occurring cytotoxic alkaloid 2-(4-oxo-3,4-dihydroquinazolin-2-yl)-1H-indole-3- carbaldehyde (bouchardatine).

MULTICYCLIC LONIDAMINE ANALOGS

The invention provides lonidamine analogs as well as methods of treating cancer and BPH.

COPPER(I)-PROMOTED COUPLING REACTION OF ARYL HALIDES WITH SODIUM DIETHYLMALONATE

Copper(I)-promoted coupling reaction of aryl halides with sodium diethylmalonate occured smoothly in dioxane.The qualitative trends in the activity of copper(I) salt followed the order: CuBr > CuI > CuBF4(CH3CN)4 > CuCl.The activity was lowered in the presence of coordinating molecule such as acetonitrile, pyridine, NaI, phosphine, and sulfide.The reaction was generally applicable to aryl halides with various substituents.