344403-86-7Relevant articles and documents
Synthesis of the extracellular Ig domain I of Emmprin carrying a chitobiose unit
Hojo, Hironobu,Watabe, Jun,Nakahara, Yoshiaki,Nakahara, Yuko,Ito, Yukishige,Nabeshima, Kazuki,Toole, Bryan P.
, p. 3001 - 3004 (2001)
The extracellular Ig domain I of Emmprin (34-94) carrying a chitobiose unit at Asn44 was chemically synthesized. Boc-Asn with a benzyl-protected chitobiose unit was synthesized and used for the preparation of peptide thioester with the sequence of Emmprin (34-58) by Boc strategy. C-Terminal peptide amide (59-94) was also prepared by the solid-phase method. These segments were condensed by activation of the thioester group by silver ions to obtain a protected form of Emmprin (34-94)-NH2. After deprotection and air oxidation, the desired Emmprin (34-94)-NH2 with chitobiose was successfully obtained.