344463-04-3

Basic information

• Product Name: 2,2,2-Trifluoro-N-{2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethyl}-acetamide
• Synonyms: 2,2,2-Trifluoro-N-{2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethyl}-acetamide
• CAS NO: 344463-04-3
• Molecular Weight: 343.154
• Mol File: 344463-04-3.mol

Chemical Properties

• CAS DataBase Reference: 2,2,2-Trifluoro-N-{2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethyl}-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-Trifluoro-N-{2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethyl}-acetamide(344463-04-3)
• EPA Substance Registry System: 2,2,2-Trifluoro-N-{2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethyl}-acetamide(344463-04-3)

Safety Data

• Hazardous Substances Data: 344463-04-3(Hazardous Substances Data)

Upstream product

• 308336-42-7 2,2,2-Trifluoro-N-(2-(4-iodophenyl)ethyl)acetamide 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 458-85-5 2,2,2-trifluoro-N-(2-phenylethyl)acetamide 
• 73183-34-3 bis(pinacol)diborane 
• 64-04-0 phenethylamine 
• 76-09-5 2,3-dimethyl-2,3-butane diol 

Downstream Products

• 360792-42-3 tert-butyl {2,2,2-trifluoro-N-[2-(4-(boronic acid)phenyl)ethyl]acetylamino}formate, pinacol ester 
• 360792-43-4 tert-butyl N-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl]carbamate 

Relevant articles and documents

meta-Selective C?H Borylation of Benzylamine-, Phenethylamine-, and Phenylpropylamine-Derived Amides Enabled by a Single Anionic Ligand

Selective functionalization at the meta position of arenes remains a significant challenge. In this work, we demonstrate that a single anionic bipyridine ligand bearing a remote sulfonate group enables selective iridium-catalyzed borylation of a range of common amine-containing aromatic molecules at the arene meta position. We propose that this selectivity is the result of a key hydrogen bonding interaction between the substrate and catalyst. The scope of this meta-selective borylation is demonstrated on amides derived from benzylamines, phenethylamines and phenylpropylamines; amine-containing building blocks of great utility in many applications.

Sulfonamide derivatives

The present invention provides certain sulfonamide derivatives useful for potentiating glutamate receptor function in a patient and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.