308336-42-7

Basic information

• Product Name: 2,2,2-Trifluoro-N-[2-(4-iodophenyl)ethyl]acetamide
• Synonyms: 2,2,2-Trifluoro-N-[2-(4-iodophenyl)ethyl]acetamide
• CAS NO: 308336-42-7
• Molecular Formula: C₁₀H₉F₃INO
• Molecular Weight: 343.0842396
• Mol File: 308336-42-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,2,2-Trifluoro-N-[2-(4-iodophenyl)ethyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-Trifluoro-N-[2-(4-iodophenyl)ethyl]acetamide(308336-42-7)
• EPA Substance Registry System: 2,2,2-Trifluoro-N-[2-(4-iodophenyl)ethyl]acetamide(308336-42-7)

Safety Data

• Hazardous Substances Data: 308336-42-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,2,2-Trifluoro-N-[2-(4-iodophenyl)ethyl]acetamide is used as a building block for the synthesis of various organic compounds. Its unique structure and reactivity allow for the creation of a wide range of molecules with different properties and applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2,2,2-Trifluoro-N-[2-(4-iodophenyl)ethyl]acetamide is used as an intermediate in the synthesis of pharmaceutical drugs and bioactive compounds. Its role in the development of new therapeutic agents is crucial, as it can contribute to the creation of molecules with improved efficacy, safety, and pharmacokinetic profiles.
Used in Drug Development:
2,2,2-Trifluoro-N-[2-(4-iodophenyl)ethyl]acetamide is employed as a key component in the design and synthesis of new drug candidates. Its presence in the molecular structure can influence the drug's interaction with biological targets, potentially leading to more effective treatments for various diseases and conditions.

Upstream product

• 64-04-0 phenethylamine 
• 458-85-5 2,2,2-trifluoro-N-(2-phenylethyl)acetamide 
• 7553-56-2 iodine 

Downstream Products

• 344463-04-3 2,2,2-Trifluoro-N-{2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethyl}-acetamide 
• 360792-43-4 tert-butyl N-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl]carbamate 
• 360792-42-3 tert-butyl {2,2,2-trifluoro-N-[2-(4-(boronic acid)phenyl)ethyl]acetylamino}formate, pinacol ester 
• 308336-43-8 2-Iodo-5-(2-(2,2,2-trifluoroacetamido)ethyl)benzenesulfonamide 

Relevant articles and documents

Direct ortho iodination of β- and γ-aryl alkylamine derivatives

Two in one! A trifluoroacetamide protecting group not only masks an amine functionality, but also mimics peptidyl directing effects as a controlling unit in an efficient ortho iodination of a variety of biologically relevant small molecules (see example). (Chemical Equation Presented).

Sulfonamide derivatives

The present invention provides certain sulfonamide derivatives useful for potentiating glutamate receptor function in a patient and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.

Acylaminoalkyl-substituted benzenesulfonamide derivatives, their preparation, their use and pharmaceutical preparations comprising them

One embodiment of the present invention relates to acylaminoalkyl-substituted benzenesulfonamide derivatives of the formula (I), 1in which A, R(1), R(2), X, Y, and Z have the meanings indicated in the specification, and to pharmaceutically tolerable salt

Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives, processes for their preparation, their use, and pharmaceutical preparations comprising them

The present invention relates to cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives of formula I in which A(1), A(2), A(3), R(1), R(2), R(3), R(4), X, Y, and Z have the meanings indicated in the claims. Compounds of formula I are valuable pharmaceutical active compounds which exhibit, for example, an inhibitory action on ATP-sensitive potassium channels in the cardiac muscle and/or in the cardiac nerve and are suitable, for example, for the treatment of disorders of the cardiovascular system such as coronary heart disease, arrhythmias, cardiac insufficiency or cardiomyopathies, or for the prevention of sudden cardiac death, or for improving decreased contractility of the heart. The invention furthermore relates to processes for the preparation of compounds of formula I, their use, and pharmaceutical preparations comprising them.

Heteroarylacryloylaminoalkyl-substituted benzenesulfonamide derivatives, their preparation, their use and pharmaceutical preparations comprising them

One embodiment of the present invention relates to heteroarylacryloylaminoalkyl-substituted benzenesulfonamide derivatives of the formula (I), in which R(1), R(2), R(3), R(4), Het, X, Y and Z have the meanings indicated in the specification, and to pharma