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344463-37-2

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344463-37-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 344463-37-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,4,4,6 and 3 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 344463-37:
(8*3)+(7*4)+(6*4)+(5*4)+(4*6)+(3*3)+(2*3)+(1*7)=142
142 % 10 = 2
So 344463-37-2 is a valid CAS Registry Number.

344463-37-2Downstream Products

344463-37-2Relevant articles and documents

CYCLOBUTENEDIONE DERIVATIVES

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Page/Page column 81, (2010/12/17)

The present invention relates to compounds of the formula (I): to pharmaceutically acceptable salts therefore and to pharmaceutically acceptable solvates of said compounds and salts, wherein the substituents are defined herein; to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly inflammatory conditions.

Design and synthesis of a novel series of 1,2-disubstituted cyclopentanes as small, potent potentiators of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) receptors

Shepherd, Timothy A.,Aikins, James A.,Bleakman, David,Cantrell, Buddy E.,Rearick, John P.,Simon, Richard L.,Smith, Edward C. R.,Stephenson, Gregory A.,Zimmerman, Dennis M.,Mandelzys, Allan,Jarvie, Keith R.,Ho, Ken,Deverill, Michelle,Kamboj, Rajender K.

, p. 2101 - 2111 (2007/10/03)

2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) potentiators are ligands that act as positive allosteric modulators at the AMPA receptors. We recently disclosed a novel series of 2-arylpropylsulfonamides that were potent potentiators of responses mediated through AMPA receptors. To further define the structural requirements for activity in this series, new ring-constrained analogues were prepared and a new stereocenter was introduced. The potentiating activity was highly dependent on the stereochemistry at the 2-position of the disubstituted cyclopentane and was independent of the relative stereochemistry at the 1-position. Compound (R,R)-10 represents a potent, novel potentiator of iGluR4 flip receptors (EC50 = 22.6 nM).

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