344550-17-0Relevant academic research and scientific papers
Synthesis of indole and indolenine derivatives starting from indoline-2-thiones
Nishio,Saku,Yamamoto
, p. 105 - 108 (2001)
Indoline-2-thiones 1a-b,d,f,h, which have at least one hydrogen at the 3-position reacted with α-halo ester 2a-d, α-halo ketones 2e-f, and α-bromoacetonitrile 2g to give 2-alkylthioindole derivatives 3-11. In a similar manner treatment of 3,3-disubstituted indoline-2-thiones 1c,e with α-halo esters 2a,c,d and α-halo ketone 2e gave 2-alkylthioindolenines 12-16. Treatment of 1,3,3- trisubstituted indoline-2-thiones 1g,i with ethyl bromo-acetate 2a resulted in recovery of starting materials. Desulfurization of indolenine 14 with triphenylphosphine gave 2-alkylideneindoline 19.
