34456-60-5Relevant academic research and scientific papers
Synthesis of pyrido[1,2-b]indazoles via aryne [3+2] cycloaddition with N-tosylpyridinium imides
Zhao, Jingjing,Wu, Chunrui,Li, Pan,Ai, Wenying,Chen, Hongli,Wang, Chaojie,Larock, Richard C.,Shi, Feng
, p. 6837 - 6843 (2011)
The [3 + 2] cycloaddition of arynes with N-tosylpyridinium imides, followed by an elimination of Ts-, affords pyrido[1,2-b]indazoles under mild reaction conditions in good yields.
Synthesis of Some N-(Phenylsulfonylamino)-1,2,3,6-tetrahydropyridines as Potential Anti-inflammatory Agents
Choi, JongOh,Wilson, Tiffany L.,Ly, Ana M.,Okoro, Cosmas O.,Onubogu, Udobi C.,Redda, Kinfe K.
, p. 281 - 295 (2007/10/03)
Several N-(phenylsulfonylamino)-1,2,3,6-tetrahydropyridines were synthesized by substituting a sulfonyl group for the carbonyl group of N-(phenylcarbonylamino)-1,2,3,6-tetrahydropyridines 1 in order to investigate the effect of the substitution on the analgesic and anti-inflammatory activities. Nucleophilic attack of pyridine derivatives 2 on 1-chloro-2,4-dinitrobenzene 3 furnished the pyridinium chlorides 4. Compound 4 and benzenesulfonyl hydrazide 5 were reacted to give the 2,4-dinitroanilino derivatives 6. Hydrolysis of 6 furnished the ylides 7. Sodium borohydride reduction of ylides afforded the tetrahydropyridines 8. Compound 8c was found to be the most active anti-inflammatory agent and was as potent as indomethacin, the reference compound. Compound 8f had the most significant hyperglycemic activity.
