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344569-55-7

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344569-55-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 344569-55-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,4,5,6 and 9 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 344569-55:
(8*3)+(7*4)+(6*4)+(5*5)+(4*6)+(3*9)+(2*5)+(1*5)=167
167 % 10 = 7
So 344569-55-7 is a valid CAS Registry Number.

344569-55-7Downstream Products

344569-55-7Relevant articles and documents

In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives

Moreno-Viguri, Elsa,Jiménez-Montes, Carmen,Martín-Escolano, Rubén,Santiva?ez-Veliz, Mery,Martin-Montes, Alvaro,Azqueta, Amaya,Jimenez-Lopez, Marina,Zamora Ledesma, Salvador,Cirauqui, Nuria,López De Ceráin, Adela,Marín, Clotilde,Sánchez-Moreno, Manuel,Pérez-Silanes, Silvia

, p. 10929 - 10945 (2016)

Chagas disease is a neglected tropical disease with 6-7 million people infected worldwide, and there is no effective treatment. Therefore, there is an urgent need to continue researching in order to discover novel therapeutic alternatives. We present a series of arylaminoketone derivatives as means of identifying new drugs to treat Chagas disease in the acute phase with greater activity, less toxicity, and a larger spectrum of action than that corresponding to the reference drug benznidazole. Indexes of high selectivity found in vitro formed the basis for later in vivo assays in BALB/c mice. Murine model results show that compounds 3, 4, 7, and 10 induced a remarkable decrease in parasitemia levels in acute phase and the parasitemia reactivation following immunosuppression, and curative rates were higher than with benznidazole. These high antiparasitic activities encourage us to propose these compounds as promising molecules for developing an easy to synthesize anti-Chagas agent.

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