344592-46-7Relevant academic research and scientific papers
Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity
Reichenberg, Armin,Wiesner, Jochen,Weidemeyer, Claus,Dreiseidler, Erhard,Sanderbrand, Silke,Altincicek, Boran,Beck, Ewald,Schlitzer, Martin,Jomaa, Hassan
, p. 833 - 835 (2001)
The fosmidomycin derivative FR900098 represents an inhibitor of the 1-deoxy-D-xylulose 5-phosphate (DOXP) reductoisomerase with potent antimalarial activity. Prodrugs of FR900098 with increased activity after oral administration were obtained by chemical modification of the phosphonate moiety to yield phosphodiaryl esters. One diaryl ester prodrug demonstrated efficacy in mice infected with the rodent malaria parasite Plasmodium vinckei comparable to ip drug administration.
