86483-94-5

Usage

Uses

Used in Organic Synthesis:
(3-bromopropyl)phosphonic dichloride is used as a reagent for the functionalization of organic molecules. Its unique structure allows for the introduction of phosphonic acid groups into various organic compounds, which can enhance their properties or enable new reactions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (3-bromopropyl)phosphonic dichloride is used as a building block for the synthesis of complex organic molecules, including potential drug candidates. Its ability to form phosphonic acid derivatives can be leveraged to create novel bioactive compounds with therapeutic potential.
Used in Chemical Research:
(3-bromopropyl)phosphonic dichloride is also utilized in chemical research for studying the reactivity and properties of phosphonic acid derivatives. Its unique structure provides a platform for exploring new reaction pathways and understanding the fundamental chemistry of phosphorus-containing compounds.
Used in Material Science:
In the field of material science, (3-bromopropyl)phosphonic dichloride can be employed as a precursor for the development of new materials with specific properties. The incorporation of phosphonic acid groups can lead to materials with improved stability, reactivity, or other desirable characteristics.

Upstream product

• 1190-09-6 3-bromopropane-1-phosphonic acid 
• 118559-23-2 bis(trimethylsilyl) (3-bromopropyl)phosphonate 

Downstream Products

• 344592-46-7 (3-bromo-propyl)-phosphonic acid di-o-tolyl ester 
• 344592-47-8 (3-bromo-propyl)-phosphonic acid bis-(4-methoxy-phenyl) ester 
• 344592-45-6 [3-bromopropyl(phenoxy)phosphoryl]oxybenzene 
• 1186-10-3 diethyl 3-(bromopropyl)phosphonic acid 

Relevant academic research and scientific papers

Reaction of dibromoalkanes with silyl phosphites. Synthesis and properties of mono-and diphosphonoalkanes

Reactions of dibromoethane and dibromopropane with silyl phosphites are studied. Mono-and diphosphonoalkanes of various structures were prepared, and their chemical properties were studied. Pleiades Publishing, Inc., 2006.

Experimental and theoretical investigation of intramolecular transformations of silicon-containing (haloalkyl)phosphorylated ureas and acylamides

Silicon-containing chloromethylphosphorylated ureas undergo transformation involving evolution of chlorotrimethylsilane and formation of 1,3,4-oxazaphospholes. Their analogs, silicon-containing phosphorylated acylamides, transform in another way, viz. by

Synthesis and interfacial behavior of sulfur-containing analogs of lung surfactant dipalmitoyl phosphatidylcholine

The synthesis and potential of lipids 2 and 3 to act as lung surfactants is reported. Synthesis methods and initial surface property characterizations are reported for two sulfur-containing phosphonolipids related structurally to dipalmitoyl phosphatidylc

Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity

The fosmidomycin derivative FR900098 represents an inhibitor of the 1-deoxy-D-xylulose 5-phosphate (DOXP) reductoisomerase with potent antimalarial activity. Prodrugs of FR900098 with increased activity after oral administration were obtained by chemical modification of the phosphonate moiety to yield phosphodiaryl esters. One diaryl ester prodrug demonstrated efficacy in mice infected with the rodent malaria parasite Plasmodium vinckei comparable to ip drug administration.

Cationic phosphonolipids containing quaternary phosphonium and arsonium groups for DNA transfection with good efficiency and low cellular toxicity

Replacing the ammonium polar head in cationic lipids 1 (A = N) by a phosphonium or an arsonium group (A=P, As) improves their properties as synthetic vectors for DNA transfection. The increased volume of the cationic head is supposed to modify the interactions of the vector with the solvent and DNA.

EXPEDIENT AND HIGH-YIELD SYNTHESIS OF ALKYLPHOSPHONYL DICHLORIDES UNDER MILD, NEUTRAL CONDITIONS: REACTION OF BIS(TRIMETHYLSILYL)ALKYL PHOSPHONATES WITH OXALYL CHLORIDE/DIMETHYLFORMAMIDE

Structurally variant bis(trimethylsilyl)alkyl phosphonates were converted in high yields (80-88percent, distilled) to the corresponding phosphonyl dichlorides upon reaction with (COCl)2/DMF.