3446-05-7

Basic information

• Product Name: 1,3-Benzenediol, 4-chloro-5-methyl-
• Synonyms: 1,3-Benzenediol, 4-chloro-5-methyl-;4-Chloro-5-methyl-1,3-benzenediol;4-Chloro-5-methylbenzene-1,3-diol;4-Chloro-5-methylresorcinol;4-Chloroorcinol
• CAS NO: 3446-05-7
• Molecular Formula: C₇H₇ClO₂
• Molecular Weight: 158.58
• Mol File: 3446-05-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 138-139 °C
• Boiling Point: 277.5°Cat760mmHg
• Flash Point: 121.6°C
• Appearance: /
• Density: 1.384g/cm³
• Vapor Pressure: 0.00267mmHg at 25°C
• Refractive Index: 1.61
• PKA: 8.39±0.15(Predicted)
• CAS DataBase Reference: 1,3-Benzenediol, 4-chloro-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Benzenediol, 4-chloro-5-methyl-(3446-05-7)
• EPA Substance Registry System: 1,3-Benzenediol, 4-chloro-5-methyl-(3446-05-7)

Safety Data

• Hazardous Substances Data: 3446-05-7(Hazardous Substances Data)

Usage

Derivative of

hydroquinone

Industrial applications

a. Synthesis of pharmaceuticals
b. Synthesis of agrochemicals
c. Synthesis of other organic compounds

Additional uses

a. Production of dyes
b. Production of pigments
c. Production of antioxidants

Physical state

solid, white powder

Solubility

soluble in water and organic solvents

Health hazards

potential irritant to skin, eyes, and respiratory system

Environmental impact

toxic effects on aquatic organisms, potential environmental pollutant

InChI:InChI=1/C7H7ClO2/c1-4-2-5(9)3-6(10)7(4)8/h2-3,9-10H,1H3

Upstream product

• 57074-23-4 ethyl 5-chloro-orsellinate 
• 2524-37-0 ethyl orselinate 
• 3187-58-4 methyl orsellinate 
• 83324-60-1 4,6-dichloro-5-methyl-1,3-cyclohexanedione 
• 504-15-4 orcinol 

Downstream Products

• 861071-95-6 4-chloro-5-methyl-6-nitroso-resorcinol 
• 68048-24-8 2,4,4',6,6'-Pentabenzyloxy-3,3'-dichlor-2'-methylbenzophenon 
• 68048-32-8 3,3'-Dichlor-2,4,4',6,6'-pentahydroxy-2'-methyl-benzophenon 
• 101292-45-9 1,5-diacetoxy-2-chloro-4-diacetoxymethyl-3-methyl-benzene 
• 112990-33-7 3-chloro-4,6-bis-methoxycarbonyloxy-2-methyl-benzaldehyde 
• 30448-89-6 3-chloro-4,6-dihydroxy-2-methylbenzoic acid 
• 78135-39-4 2,2',4,4'-tetrabenzyloxy-3,5,5'-trichloro-6,6'-dimethylbenzophenone 
• 78135-36-1 2,2',4'-tribenzyloxy-3,5,5'-trichloro-4-methoxy-6,6'-dimethylbenzophenone 
• 78135-51-0 3-chloro-6-(3,5-dichloro-2-hydroxy-4-methoxy-6-methylphenoxy)-4-hydroxy-2-methylbenzoic acid 
• 69709-89-3 3,5,5'-trichloro-2,2',4'-trihydroxy-4-methoxy-6,6'-dimethylbenzophenone 
• 69709-91-7 3,5,5'-trichloro-2,2',4,4'-tetrahydroxy-6,6'-dimethylbenzophenone 
• 69769-50-2 methyl 3-chloro-6-(3,5-dichloro-2-hydroxy-4-methoxy-6-methylphenoxy)-4-hydroxy-2-methylbenzoate 
• 83324-59-8 3-chloro-4,6-dihydroxy-2-methyl-benzaldehyde 
• 68048-11-3 3,5-dibenzyloxy-2-chlorotoluene 

Relevant articles and documents

Synthesis of chloro-substituted 6H-dibenzo[b,d]pyran-6-one natural products, graphislactone G, and palmariols A and B

A palladium-mediated intramolecular aryl–aryl coupling reaction was applied to the total synthesis of the bioactive natural products, graphislactone G (1), and palmariols A (2) and B (3), which possess an unusual chloro-subsutituent on the 6H-dibenzo[b,d]

A GENERAL SYNTHETIC METHOD FOR PRENYLATED PHENOLS OF MICROBIAL ORIGIN

Prenylated phenols with a fully substituted benzene ring, such as colletochlorins A and B, were synthesized by first prenylating 1,5-dimethoxy-3-methyl-1,4-cyclohexadiene and then effecting the aromatization of the prenylated product.