3447-02-7

Usage

Uses

Used in Pharmaceutical Production:
2-HEXYLPYRROLIDINE is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new medications due to its chemical properties and reactivity.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2-HEXYLPYRROLIDINE is employed as a synthetic intermediate, playing a crucial role in the creation of compounds that protect crops and enhance agricultural productivity.
Used in Chemical Intermediates:
2-HEXYLPYRROLIDINE is utilized as a key component in the production of a wide range of chemical intermediates, which are essential for the synthesis of various end products in the chemical industry.
Used in Consumer Product Formulation:
2-HEXYLPYRROLIDINE is used as a component in certain consumer products such as personal care items and household cleaners, leveraging its properties to enhance product performance and safety.
Used in Industrial Applications as a Solvent:
2-HEXYLPYRROLIDINE's role as a solvent in industrial applications is significant, providing a medium for chemical reactions and contributing to the efficiency of various processes due to its stability and low volatility.

Upstream product

• 111-71-7 heptanal 
• 629-08-3 heptanenitrile 
• 116437-48-0 3,4-dihydro-5-hexyl-2H-pyrrole 
• 118282-73-8 2-<1-(hex-5-enyl)>-1-pyrroline 

Relevant academic research and scientific papers

Synthesis of Highly Enantiomerically Enriched Cyclic Amines by the Catalytic Asymmetric Hydrogenation of Cyclic Imines

The asymmetric hydrogenation of cyclic ketimines with a chiral titanocene catalyst affords amines with excellent enantioselectivity under a variety of conditions.The reaction is general for cyclic imines of ring size 5-7 and exhibits a high degree of functional group compatibility.

Synthesis of 2-substituted pyrrolidines from nitriles

A novel and synthetically facile production of 2-substituted pyrrolidines from commercially available nitriles is reported herein. This methodology is operationally simple, and only requires the use of an extraction and a single chromatographic purificati

Azidomercurations of alkenes: Mercury-promoted Schmidt reactions

Azides bearing a suitably disposed alkene, when treated with either mercuric perchlorate or mercuric trifluoromethanesulfonate, produce bicyclic iminium ions. This new version of the Schmidt reaction proceeds by capture of the mercuronium ion intermediate by the azide to produce an aminodiazonium ion, which suffers a 1,2-shift to give an iminium ion (e.g., 10 → 16 → 17 → 18). Reduction of the iminium ion may then be carried out to produce an amine. Compared to earlier work on the protic acid-promoted intramolecular Schmidt reaction of azido-alkenes, the mercury-promoted Schmidt reaction has several advantages. First, the acid-promoted Schmidt reaction of azido-alkenes requires that the intermediate carbocations be tertiary, allylic, benzylic, or propargylic. The mercury-promoted method has no such limitation; thus even 1,2-disubstituted alkenes may be used. Second, the mercury-promoted method is milder, allowing the presence of acid-sensitive functionality. The protic version, typically employing trifluoromethanesulfonic acid, is limited in its functional group tolerance. Third, whereas carbocation rearrangement is often observed prior to cyclization/rearrangement in the acid-promoted Schmidt reaction, the mercury-promoted method avoids this problem. Fourth, the presence of the mercurio group during the rearrangment may alter the regioselectivity of the 1,2-migration. Finally, the mercury-bearing iminium ions that are the result of the Schmidt reaction were found to be sensitive to protodemercuration, precluding their use in other transformations.