Synthesis of Highly Enantiomerically Enriched Cyclic Amines by the Catalytic Asymmetric Hydrogenation of Cyclic Imines

Article abstract of DOI:10.1021/jo00079a001

The asymmetric hydrogenation of cyclic ketimines with a chiral titanocene catalyst affords amines with excellent enantioselectivity under a variety of conditions.The reaction is general for cyclic imines of ring size 5-7 and exhibits a high degree of functional group compatibility.