344906-03-2

Upstream product

• 344906-02-1 1-[1'-O-methylsulfonyl-3',4'-O-isopropylidene-6'-O-(4-toluoyl)-β-D-psicofuranosyl]thymine 
• 34626-95-4 1,2:3,4-di-O-isopropylidene-β-D-psicofuranose 
• 874-60-2 4-methyl-benzoyl chloride 
• 65-71-4 thymin 
• 344905-99-3 6-O-(4-toluoyl)-1,2:3,4-di-O-isopropylidene-β-D-psicofuranose 
• 344906-00-9 1-[3',4'-O-isopropylidene-6'-O-(4-toluoyl)-β-D-psicofuranosyl]thymine 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 

Downstream Products

• 344906-04-3 1-[1',3'-anhydro-6'-O-(4-toluoyl)-β-D-psicofuranosyl]thymine 
• 344906-05-4 1-[1',3'-anhydro-6'-O-(4,4'-dimethyoxytrityl)-β-D-psicofuranosyl]thymine 

Relevant academic research and scientific papers

Conformation-specific cleavage of antisense oligonucleotide-RNA duplexes by RNase H

The North-form (3'-endo) constrained 1-(1',3'-O-anhydro-β-D-psicofuranosyl)thymine block, , was systematically incorporated at various sites, one at a time, into a set of four antisense oligonucleotides (AONs). The hybrids of these AONs with a matched