344930-94-5Relevant academic research and scientific papers
A novel orally active inhibitor of HLE
Varga, Marton,Kapui, Zoltan,Batori, Sandor,Nagy, Lajos T.,Vasvari-Debreczy, Lelle,Mikus, Endre,Urban-Szabo, Katalin,Aranyi, Peter
, p. 421 - 425 (2003)
Human leukocyte elastase (HLE) is a serine proteinase, capable of degrading a variety of structural matrix proteins. SSR69071 2-[(4-isopropyl-6-methoxy-1,1-dioxido-3-oxo-1,2-benzisothiazol-2( 3H)-yl) methoxy]-9-(2-piperidin-1-ylethoxy)-4H-pyrido[1,2-a]pyrimidin-4-o ne was selected as a novel orally active HLE inhibitor for treatment of chronic obstructive pulmonary diseases, asthma, emphysema, cystic fibrosis and several inflammatory diseases (WO 01/44245 A1) (J. Pharm. Exp. Ther., submitted for publication).
