344940-70-1

Basic information

• Product Name: 2-Amino-5-bromo-3-phenylpyrazine
• Synonyms: 2-Amino-5-bromo-3-phenylpyrazine;5-BroMo-3-phenylpyrazin-2-aMine
• CAS NO: 344940-70-1
• Molecular Formula: C₁₀H₈BrN₃
• Molecular Weight: 250.09462
• Mol File: 344940-70-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-Amino-5-bromo-3-phenylpyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-bromo-3-phenylpyrazine(344940-70-1)
• EPA Substance Registry System: 2-Amino-5-bromo-3-phenylpyrazine(344940-70-1)

Safety Data

• Hazardous Substances Data: 344940-70-1(Hazardous Substances Data)

Usage

Description

2-Amino-5-bromo-3-phenylpyrazine is a chemical compound with the molecular formula C10H8BrN3. It is a pyrazine derivative with a bromine atom at the 5th position and an amino group at the 2nd position, as well as a phenyl group attached to the 3rd carbon.

Uses

Used in Pharmaceutical Industry:
2-Amino-5-bromo-3-phenylpyrazine is used as a building block for the synthesis of new drug molecules. It has potential applications in medicinal chemistry, particularly for creating new drugs with potential anti-cancer, anti-inflammatory, or antimicrobial properties.
Used in Agrochemical Research:
2-Amino-5-bromo-3-phenylpyrazine is used as an intermediate in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural chemicals.
Used in Dye Synthesis:
2-Amino-5-bromo-3-phenylpyrazine is also used as an intermediate in the synthesis of dyes, playing a role in the creation of various colorants for different industries.

Upstream product

• 24241-18-7 2-amino-3,5-dibromopyrazine 
• 98-80-6 phenylboronic acid 
• 41270-67-1 2-Amino-3-phenylpyrazine 
• 960-16-7 tributylphenylstannane 

Downstream Products

• 41270-70-6 2-amino-3,5-diphenylpyrazine 
• 625848-40-0 5-(4-[tert-butyl(dimethyl)silyloxy]phenyl)-3-phenyl-2-pyrazinamine 
• 1202278-29-2 tert-butyl 5-(5-amino-6-phenylpyrazin-2-yl)thiazol-2-yl(isopropyl)carbamate 
• 1202278-30-5 tert-butyl isopropyl(5-(8-phenylimidazo[1,2-a]pyrazin-6-yl)thiazol-5-yl)carbamate 
• 1202277-75-5 N-isopropyl-5-(8-phenylimidazo[1,2-a]pyrazin-6-yl)thiazol-2-amine 

Relevant articles and documents

Heterocyclic Adenosine Receptor Antagonists

Heterocyclic compounds useful as antagonists of adenosine receptors, and methods of treatment of diseases using antagonists of adenosine receptors are disclosed herein. Also disclosed herein are pharmaceutical compositions and methods of administration of

Selectfluor-promoted regioselective chlorination/bromination of 2-aminopyridines and 2-aminodiazines using LiCl/LiBr

Using LiCl as a chlorine source, the chlorination of 2-aminopyridines or 2-aminodiazines in the presence of Selectfluor and DMF is established under mild conditions. This method gives chlorinated pyridines or diazines in good to high yields with high regioselectivities. Also, this method is extended to the bromination of 2-aminopyridines or 2-aminodiazines by using LiBr. The regioselectivity of the chlorination reaction is strongly dependent upon the substituent pattern in either the 2-aminopyridines or 2-aminodiazines. The synthesis of Buparlisib from chlorinated pyridines was explored. A study of the mechanism revealed that this chlorination occurs via either a pyridine or diazine radical process.

TRIAZOLOPYRIDINE COMPOUNDS USEFUL AS KINASE INHIBITORS

A compound of Formula (I) and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula (I), and methods of treating conditions associated with the activity of