344943-62-0Relevant academic research and scientific papers
Synthesis and investigation of antimicrobial activity of some nifuroxazide analogues
Alsaeedi, Huda S.,Aljaber, Nabila A.,Ara, Ismet
, p. 3639 - 3646 (2015/12/26)
A series of nifuroxazide analogues [(2a-2e)-(10a-10f)] have been synthesized, structurally identified and tested for antimicrobial activity against a panel of bacteria (Gram-positive and Gram-negative) and the yeast-like pathogenic fungus Candida albicans. The most active compound in this series was 4-amino-benzoic acid (5-nitro-furan-2-ylmethylene)-hydrazide (2b) and 2-amino-benzoic acid (5-nitrofuran-2-ylmethylene)-hydrazide (2d). Furthermore, compounds (9a-9g) and (10a-10g) recorded no activity against selected species except compounds (9f) and (10f) suggesting that using furoic hydrazide and the corresponding hydrazide of thiophene did not improve the antimicrobial activities for this type of compounds. Regarding the activity against Candida albicans, all compounds showed no activity with an exception of substituted nitro furan (2a-2d).
Synthesis of 5-aryl-2-furaldehyde arylsulfonylhydrazones and their transformations in the Bamford-Stevens reaction
Dzikovskaya,Ganushchak
, p. 1346 - 1352 (2007/10/03)
Reactions of arenesulfonohydrazides with 5-aryl-2-furaldehydes in anhydrous ethanol or dioxane afforded a series of the corresponding arylsulfonylhydrazones which reacted with alcoholic sodium alkoxides with liberation of nitrogen and formation of 2-alkoxymethyl-5-arylfurans. Thermolysis of 5-aryl-2-furaldehyde tosylhydrazones in aqueous sodium hydroxide, diethylamine, or morpholine is accompanied by evolution of ～50% of the theoretical amount of nitrogen. The major thermolysis products (yield 70-82%) are 5-aryl-2-furaldehyde N-(5-aryl-2-furylmethyl)tosylhydrazones; also, small amounts (2-3%) of 5-arylfurfuryl alcohols and bis(5-arylfurfuryl) ethers are formed.
