345-68-6

Upstream product

• 321-28-8 1-fluoro-2-methoxybenzene 
• 774-65-2 benzoic acid tert-butyl ester 
• 100-58-3 phenylmagnesium bromide 
• 1258221-87-2 (3-fluoro-4-methoxyphenyl)(phenyl)methanol 
• 351-54-2 3-fluoro-p-anisaldehyde 

Downstream Products

• 365-14-0 3-fluoro-4-hydroxybenzophenone 
• 579-15-7 3-bromo-5-fluoro-4-hydroxy-benzophenone 

Relevant academic research and scientific papers

MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF

The disclosure relates to compounds and pharmaceutical compositions capable of modulating the hydroxysteroid 17-beta dehydrogenase (HSD17B) family member proteins including inhibiting the HSD17B member proteins, e.g. HSD17B13. The disclosure further relates to methods of treating liver diseases, disorders, or conditions with the compounds and pharmaceutical compositions disclosed herein, in which the HSD17B family member protein plays a role.

Esters as acylating reagent in a Friedel-Crafts reaction: Indium tribromide catalyzed acylation of arenes using dimethylchlorosilane

(Chemical Equation Presented) The Friedel-Crafts acylation of arenes with esters by dimethylchlorosilane and 10 mol % of indium tribromide has been achieved. The key intermediate RCOOSi(Cl)Me2 is generated from alkoxy esters with the evolution of the corresponding alkanes. The scope of the alkoxy ester moiety was wide: tert-butyl, benzyl, allyl, and isopropyl esters were successful. In addition, we demonstrated the direct synthesis of the indanone intermediate 11 of salviasperanol from ester 10.