34522-65-1Relevant academic research and scientific papers
Structural insights of SmKDAC8 inhibitors: Targeting Schistosoma epigenetics through a combined structure-based 3D QSAR, in vitro and synthesis strategy
Ballante, Flavio,Reddy, D. Rajasekhar,Zhou, Nancy J.,Marshall, Garland R.
, p. 2105 - 2132 (2017)
A predictive structure-based 3D QSAR (COMBINEr 2.0) model of the Schistosoma mansoni lysine deacetylase 8 enzyme (SmKDAC8) was developed, validated and used to perform virtual screening (VS) of the NCI Diversity Set V database (1593 compounds). Three exte
1,2,4-Benzothiadiazine-1,1-dioxide derivatives as Ionotropic glutamate receptor ligands: Synthesis and structure-activity relationships
Varano, Flavia,Catarzi, Daniela,Colotta, Vittoria,Squarcialupi, Lucia,Matucci, Rosanna
, p. 777 - 785 (2015/04/22)
Ionotropic glutamate receptor (iGluR) modulators, specially AMPA receptor antagonists, are potential tools for numerous therapeutic applications in neurological disorders, including Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, epil
