345229-22-3Relevant academic research and scientific papers
Dipeptide Phosphonates as Inhibitors of Dipeptidyl Peptidase IV
Boduszek, Bogdan,Oleksyszyn, Jozef,Kam, Chih-Min,Selzler, Joe,Smith, Robert E.,et al.
, p. 3969 - 3976 (1994)
A series of dipeptides which contained phosphonate analogs of proline and piperidine-2-carboxylic acid (homoproline) have been synthesized and tested as inhibitors of DPP-IV.The rates of inhibition of DPP-IV by these compounds are moderate, but the inhibi
A versatile and efficient ligand for copper-catalyzed formation of C-N, C-O, and P-C bonds: Pyrrolidine-2-phosphonic acid phenyl monoester
Rao, Honghua,Jin, Ying,Fu, Hua,Jiang, Yuyang,Zhao, Yufen
, p. 3636 - 3646 (2008/02/03)
A new and readily available bidentate ligand, namely, pyrrolidine-2- phosphonic acid phenyl monoester (PPAPM), has been developed for the copper-catalyzed formation of C-N, C-O, and P-C bonds, and various N-, O-, and P-arylation products were synthesized in good to excellent yields by using the CuI/PPAPM catalyst system. Addition of the PPAPM ligand greatly increases the reactivity of the copper catalyst, and the resulting versatile and efficient catalyst system is of widespread and practical application in cross-coupling reactions.
