345235-45-2

Upstream product

• 345235-40-7 3-azido-3-deoxy-1,2-O-isopropylidene-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-β-D-ribofuranose 
• 345235-41-8 Methyl 3-azido-3-deoxy-5-O-mesyl-4-C-mesyloxymethyl-D-erythro-pentofuranose 
• 345235-42-9 Methyl 3-azido-3-deoxy-2-O,4-C-methylene-D-ribofuranoside 
• 247025-10-1 3-Azido-3-deoxy-4-C-hydroxymethyl-1,2-O-isopropylidene-α-D-erythro-pentofuranose 
• 153914-98-8 3-Azido-5-O-benzoyl-4-C-benzoyloxymethyl-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose 

Relevant academic research and scientific papers

Synthesis and evaluation of anti-HIV activity of 3-azido-4-(hydroxymethyl)tetrahydrofuran derivatives containing 2-(thymin-1-yl)methyl, 2-(cytosin-1-yl)methyl or 2-(adenin-9-yl)methyl substituents - A new series of AZT analogues

The three monocyclic AZT analogues 6, 7 and 8 {3-azido-4-(hydroxymethyl)tetrahydrofuran derivatives containing 2-[(thymin-1-yl)methyl], 2-[(cytosin-1-yl)methyl] and 2-[(adenin-9-yl)methyl] substituents} are synthesized via methyl 3-azido-3-deoxy-2-O,4-C-methylene-D-ribofuranoside 13 as key intermediate. All nucleoside analogues proved to be devoid of anti-HIV activity in MT-4 cells.