345237-12-9Relevant academic research and scientific papers
Salicylamides as serine protease inhibitors
-
, (2008/06/13)
The present invention provides novel compounds of Formula I: its prodrug forms, or pharmaceutically acceptable salts thereof. The compounds of this invention are inhibitors of serine proteases, Urokinase (uPA), Factor Xa (FXa), and/or Factor VIIa (FVIIa),
4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors
Spencer, Jeffrey R,McGee, Danny,Allen, Darin,Katz, Bradley A,Luong, Christine,Sendzik, Martin,Squires, Neil,Mackman, Richard L
, p. 2023 - 2026 (2007/10/03)
The structure-based design of potent and selective urokinase-type plasminogen activator (uPA) inhibitors with 4-aminoarylamidine or 4-aminoarylguanidine S1 binding groups, is described.
