5464-07-3

Basic information

• Product Name: 3-Acetoxy-2-naphthoic acid
• Synonyms: 3-Acetoxy-2-naphthoic acid
• CAS NO: 5464-07-3
• Molecular Formula: C₁₃H₁₀O₄
• Molecular Weight: 230.2161
• Mol File: 5464-07-3.mol

Chemical Properties

• Boiling Point: 394.9°Cat760mmHg
• Flash Point: 154°C
• Appearance: /
• Density: 1.325g/cm³
• Vapor Pressure: 6.03E-07mmHg at 25°C
• Refractive Index: 1.637
• CAS DataBase Reference: 3-Acetoxy-2-naphthoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Acetoxy-2-naphthoic acid(5464-07-3)
• EPA Substance Registry System: 3-Acetoxy-2-naphthoic acid(5464-07-3)

Safety Data

• Hazardous Substances Data: 5464-07-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H10O4/c1-8(14)17-12-7-10-5-3-2-4-9(10)6-11(12)13(15)16/h2-7H,1H3,(H,15,16)

Upstream product

• 108-24-7 acetic anhydride 
• 92-70-6 3-Hydroxy-2-naphthoic acid 
• 75-36-5 acetyl chloride 

Downstream Products

• 92-77-3 2,3-oxynaphthoic acid phenylamide 
• 24445-28-1 3-hydroxy-naphthalene-2-carboxylic acid thiazol-2-ylamide 
• 81292-68-4 1,2,3,4-tetrahydronaphthalene-2-carboxaldehyde 
• 883-99-8 3-hydroxy-2-naphthoic acid methyl ester 
• 17332-04-6 methyl 2-indenecarboxylate 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 345237-12-9 N-(3-acetoxy-2-naphthoyl)-4-aminophenyl guanidine 
• 3665-51-8 3-hydroxy-2-naphthalenecarboxamide 
• 52449-77-1 3-hydroxy-2-naphthonitrile 
• 1224567-54-7 N-(4-chloro-2-hydroxyphenyl)-3-hydroxy-2-naphthamide 
• 64-19-7 acetic acid 
• 92-70-6 3-Hydroxy-2-naphthoic acid 
• 1224567-53-6 3-(3-tert-butoxycarbonylaminopropoxy)-N-(2-(3-tert-butoxycarbonyIaminopropoxy)-4-chlorophenyl)-2-naphthamide 
• 673-49-4 N-acetylhistamine 

Relevant articles and documents

Importance of equilibrium fluctuations between most stable conformers in the control of the reaction mechanism

Hydrolysis of closely related compounds show how subtle structural differences markedly change reaction mechanisms. While in the hydrolysis of 3-acetoxy-2-naphthoic acid (3AC2NA) the reacting groups rotate freely, favoring intramolecular general base catalysis, the 1-acetoxy-2-naphthoic acid (1AC2NA) isomer is caged in an energy wall that freezes a conformation suitable for intramolecular nucleophilic attack, in contrast to the results expected for reactions governed largely by electronic effects. The results highlight the importance of the dynamics of equilibrium fluctuations between most stable conformers in the control of the reaction mechanism, (i) promoting the nucleophilic attack in 1AC2NA by allowing the most stable conformers to equilibrate only via rotation in a direction that intercepts the reaction coordinate and (ii) favoring a general base-catalyzed water attack in 3AC2NA by favoring equilibration via rotation that allows inclusion of a water molecule in a proper position for reaction.

Iterative Calculation Method for Determining the Effect of Counterions on Acetylsalicylate Ester Hydrolysis in Cationic Micelles

The fraction of micellar surface neutralized is calculated from kinetic results considering independent distribution equilibria between aqueous and micellar pseudophases for different ions in solution.The new model explains the kinetic results for the basic hydrolysis of acetylsalicylic acid in cetyltrimethylammonium bromide, chloride, and hydroxyde (CTABr, CTACl, and CTAOH, respectively), and the basic hydrolysis of 3-acetoxy-2-naphthoic acid in CTAOH and CTABr.

4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

The structure-based design of potent and selective urokinase-type plasminogen activator (uPA) inhibitors with 4-aminoarylamidine or 4-aminoarylguanidine S1 binding groups, is described.

Salicylamides as serine protease inhibitors

The present invention provides novel compounds of Formula I: its prodrug forms, or pharmaceutically acceptable salts thereof. The compounds of this invention are inhibitors of serine proteases, Urokinase (uPA), Factor Xa (FXa), and/or Factor VIIa (FVIIa),

Thiazoline acid derivatives

Thiazoline acids and derivatives useful as chelators of trivalent metals in therapeutic applications have been prepared.

Synthesis and biological evaluation of naphthyldesferrithiocin iron chelators

The synthesis and iron-clearing properties of the naphthyldesferrithiocins 2-(2'-hydroxynaphth-1'-yl)-Δ2-thiazoline-(4R)-carboxylic acid, 2-(2'- hydroxynaphth-1'-yl)-Δ2-thiazoline-(4S)-carboxylic acid, 2-(3'- hydroxynaphth-2'-yl)-Δ2-thiazoline-(4R)-carboxylic acid, and 2-(3'- hydroxynaphth-2'-yl)-Δ2-thiazoline-(4S)-carboxylic acid are described. While the bile duct-cannulated rat model clearly demonstrates that the 3'- hydroxynaphth-2'-yl compounds are orally active iron-clearing agents and the corresponding 2'-hydroxynaphthyl-1'-yl compounds are not, in the primate model none of the benz-fused desazadesferrithiocin analogues are active. Oral versus subcutaneous administration of these ligands strongly suggests that metabolism is a key issue in their iron-clearing properties and that these benz-fused desferrithiocins are not good candidates for orally active iron- clearing drugs.

Influence of N-Cetyl-N,N,N-Trimethylammonium Bromide Counterions in the Basic Hydrolysis of Negatively Charged Aromatic Esters

The addition of counterions, Br-, in the basic hydrolysis of some negatively charged aromatic esters in cationic micelles of N-cetyl-N,N,N-trimethylammonium bromide displaces the substraces from the micellar phase to the aqueous phase.This effect is related to the different interactions of esters with the micelle.