345268-61-3Relevant academic research and scientific papers
Novel semi-synthetic glycopeptide antibiotics active against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE): Doubly-modified water-soluble derivatives of chloroorienticin B
Yoshida, Osamu,Yasukata, Tatsuro,Sumino, Yukihito,Munekage, Tadashi,Narukawa, Yukitoshi,Nishitani, Yasuhiro
, p. 3027 - 3031 (2007/10/03)
A series of N-alkylated and aminomethylated derivatives of chloroorienticin B, a vancomycin-related glycopeptide antibiotic, were synthesized. Doubly-modified derivatives having both hydrophobic and hydrophilic substituents exhibited potent antibacterial activity against MRSA and VRE along with considerable water-solubility.
