345319-57-5

Upstream product

• 83458-93-9 (3S)-6-(Benzyloxy)hexane-1,3-diol 
• 123-11-5 4-methoxy-benzaldehyde 
• 83458-92-8 ((2S,3S)-3-(3-(benzyloxy)propyl)oxiran-2-yl)methanol 

Downstream Products

• 198482-00-7 ent-salicylihalamide B 
• 198482-00-7 (+)-Salicylihalamide A 
• 345319-60-0 (4S,6S,7R)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-7-methyl-dec-9-en-4-ol 
• 345319-63-3 (E)-(7R,9S,10R)-9-(tert-Butyl-diphenyl-silanyloxy)-4-hydroxy-7-(3-hydroxy-propyl)-10-methyl-7,8,9,10,11,14-hexahydro-6-oxa-benzocyclododecen-5-one 
• 345319-62-2 (E)-(7R,9S,10R)-7-(3-Benzyloxy-propyl)-9-(tert-butyl-diphenyl-silanyloxy)-4-methoxy-10-methyl-7,8,9,10,11,14-hexahydro-6-oxa-benzocyclododecen-5-one 
• 345319-66-6 (E)-(7R,9S,10R)-3-[9-(tert-butyldiphenylsilanyloxy)-10-methyl-5-oxo-4-(triisopropylsilanyloxy)-7,8,9,10,11,14-hexahydro-5H-6-oxabenzocyclododecen-7-yl]propionaldehyde 
• 345319-61-1 2-Allyl-6-methoxy-benzoic acid (1R,3S,4R)-1-(3-benzyloxy-propyl)-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-hept-6-enyl ester 
• 345319-72-4 (2Z,4Z)-Hepta-2,4-dienoic acid {(Z)-3-[(E)-(7R,9S,10R)-9-(tert-butyl-diphenyl-silanyloxy)-4-hydroxy-10-methyl-5-oxo-7,8,9,10,11,14-hexahydro-5H-6-oxa-benzocyclododecen-7-yl]-propenyl}-amide 
• 345319-69-9 (2Z,4Z)-Hepta-2,4-dienoic acid {(E)-3-[(E)-(7R,9S,10R)-9-(tert-butyl-diphenyl-silanyloxy)-4-hydroxy-10-methyl-5-oxo-7,8,9,10,11,14-hexahydro-5H-6-oxa-benzocyclododecen-7-yl]-propenyl}-amide 
• 345319-71-3 (2Z,4Z)-Hepta-2,4-dienoic acid {(Z)-3-[(E)-(7R,9S,10R)-9-(tert-butyl-diphenyl-silanyloxy)-10-methyl-5-oxo-4-triisopropylsilanyloxy-7,8,9,10,11,14-hexahydro-5H-6-oxa-benzocyclododecen-7-yl]-propenyl}-amide 
• 345319-68-8 (2Z,4Z)-Hepta-2,4-dienoic acid {(E)-3-[(E)-(7R,9S,10R)-9-(tert-butyl-diphenyl-silanyloxy)-10-methyl-5-oxo-4-triisopropylsilanyloxy-7,8,9,10,11,14-hexahydro-5H-6-oxa-benzocyclododecen-7-yl]-propenyl}-amide 
• 345319-67-7 (2Z,4Z)-Hepta-2,4-dienoic acid [3-[(E)-(7R,9S,10R)-9-(tert-butyl-diphenyl-silanyloxy)-10-methyl-5-oxo-4-triisopropylsilanyloxy-7,8,9,10,11,14-hexahydro-5H-6-oxa-benzocyclododecen-7-yl]-1-((2Z,4Z)-hepta-2,4-dienoylamino)-propyl]-amide 

Relevant academic research and scientific papers

Enantioselective total synthesis of salicylihalamides A and B

We have devised a total synthesis of (12R,13S,15R) salicylihalamides A and B, which allowed revision of the absolute stereochemistry of the natural compounds. The same strategy was then applied to the preparation of naturally occurring salicylihalamides.