345349-05-5

Basic information

• Product Name: 5-iodo-1-methyl-2-phenylsulfonyl-1H-imidazole
• Synonyms: 5-iodo-1-methyl-2-phenylsulfonyl-1H-imidazole
• CAS NO: 345349-05-5
• Molecular Weight: 348.164
• Mol File: 345349-05-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-iodo-1-methyl-2-phenylsulfonyl-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-iodo-1-methyl-2-phenylsulfonyl-1H-imidazole(345349-05-5)
• EPA Substance Registry System: 5-iodo-1-methyl-2-phenylsulfonyl-1H-imidazole(345349-05-5)

Safety Data

• Hazardous Substances Data: 345349-05-5(Hazardous Substances Data)

Upstream product

• 220480-63-7 5-iodo-1-methyl-2-(phenylthio)-1H-imidazole 
• 79487-95-9 1-methyl-2-phenylsulfanyl-1H-imidazole 
• 882-33-7 diphenyldisulfane 

Downstream Products

• 1236073-89-4 2-(1-methyl-2-(phenylsulfonyl)-1H-imidazol-5-yl)phenol 
• 1448857-92-8 C₂₂H₂₄N₂O₃S 
• 1448857-93-9 5-(2-(but-3-enyloxy)phenyl)-1-methyl-2-(phenylsulfonyl)-1H-imidazole 
• 1448858-05-6 5-iodo-1-methyl-2-(4-phenylbutoxy)-1H-imidazole 
• 1448858-04-5 5-iodo-1-methyl-2-(3-phenylpropoxy)-1H-imidazole 
• 1448858-01-2 5-iodo-1-methyl-2-((2,2,3,3,4,4,5,5,6,6-undecafluorohexyl)oxy)-1H-imidazole 
• 1051373-85-3 1-methyl-5-(naphthalen-2-yl)-2-phenylsulfonyl-1H-imidazole 
• 345349-06-6 2-benzenesulfonyl-1-methyl-5-phenyl-1H-imidazole 

Relevant articles and documents

Synthesis and biological evaluation of novel imidazole-containing macrocycles

A new family of compounds made of a 5-aryl-1H-imidazole motif included in a macrocycle has been designed and synthesized. The synthesis of the imidazole core makes use of our previously developed method for the regioselective preparation of 1,2,5-trisubstituted imidazoles while the construction of the macrocycle is based on a three steps sequence: SNAr, Suzuki coupling, and RCM reaction. Biological evaluation of synthesized imidazole-containing macrocycles revealed that they display actual binding activity toward A3 adenosine (h) receptor, dopamine D1 (h) receptor, chloride channel (GABA-gated), and choline transporter (h) CHT1.

3-‘4-HETEROCYCLYL -1,2,3,-TRIAZOL-1-YL!-N-ARYL-BENZAMIDES AS INHIBITORS OF THE CYTOKINES PRODUCTION FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES

Disclosed compounds of formula (I), which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.