79487-95-9

Upstream product

• 882-33-7 diphenyldisulfane 
• 591-50-4 iodobenzene 
• 60-56-0 2-Mercapto-1-methylimidazole 
• 38111-44-3 phenylzinc(II) bromide 
• 616-47-7 1-methyl-1H-imidazole 
• 108-98-5 thiophenol 

Downstream Products

• 146744-54-9 5-benzyl-1-methyl-2-phenylthio-1-H-imidazole 
• 146744-42-5 (4-Methoxy-phenyl)-(3-methyl-2-phenylsulfanyl-3H-imidazol-4-yl)-methanol 
• 146744-45-8 5-(2,2-dimethyl-1-hydroxypropyl)-1-methyl-2-phenylthio-1H-imidazole 
• 146744-53-8 1-methyl-2,5-bis(phenylthio)-1H-imidazole 
• 351529-72-1 (RS)-[(2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxypyrrolidin-2-yl]-(1-methyl-2-phenylthioimidazol-5-yl)methanol 
• 152120-67-7 5-bromo-1-methyl-2-phenylthio-1H-imidazole 
• 220480-63-7 5-iodo-1-methyl-2-(phenylthio)-1H-imidazole 
• 244086-68-8 methyl 2-(1-methyl-1H-2-phenylthioimidazol-5-yl)glyoxylate 
• 191539-46-5 1-methyl-2-phenylthio-5-(3-hydroxypropyl)-1H-imidazole 
• 497059-31-1 (3-methyl-2-phenylsulfanyl-3H-imidazol-4-yl)-methanol 
• 465617-04-3 2-benzenesulfonyl-1-methyl-1H-imidazole 
• 304442-80-6 5-[1-hydroxy-1-(4-methoxymethoxyphenyl)methyl]-1-methyl-2-phenylthio-1H-imidazole 

Relevant academic research and scientific papers

Mild ligand-free Cu0-catalyzed chemoselective S-arylation of 2-mercaptoimidazole at low catalyst loading

A mild method for the Cu0-catalyzed chemoselective C[sbnd]S cross-coupling of 2-mercaptoimidazole derivatives with a series of with differently substituted iodobenzenes and iodothiophenes at 100 °C is described. This method proceeds efficiently without ligands and at low catalyst loading (3 mol %), without the need for stringent inert conditions. Under optimized conditions, the S-arylated products were obtained in good yields of up to 90%.

AROMATIC SULFIDE COMPOUNDS AND METHODS AND USE THEREOF

Described herein, inter alia, are aromatic sulfide compositions and methods for treating or preventing cancer using the same.

Diaryl and heteroaryl sulfides: Synthesis via sulfenyl chlorides and evaluation as selective anti-breast-cancer agents

A mild protocol for the synthesis of diaryl and heteroaryl sulfides is described. In a one-pot procedure, thiols are converted to sulfenyl chlorides and reacted with arylzinc reagents. This method tolerates functional groups including aryl fluorides and chlorides, ketones, as well as N-heterocycles including pyrimidines, imidazoles, tetrazoles, and oxadiazoles. Two compounds synthesized by this method exhibited selective activity against the MCF-7 breast cancer cell line in the micromolar range.

Copper-catalyzed direct thiolation of azoles with aliphatic thiols

Cu(ii)-catalyzed direct thiolation of azoles with thiols is described via intermolecular C-S bond formation/C-H functionalization under oxidative conditions. Both aryl thiols and aliphatic thiols are used as coupling partners, and furnished the thiolation

An efficient copper-catalyzed cross-coupling reaction of thiols with aryl iodides

Commercially available Cu2O powder is a very reactive catalyst for the coupling of thiols to aryl iodides. A variety of functional groups including esters, unprotected amines, alcohols, and heterocycles tolerate the reaction conditions. Moreover, di-ortho-substituted aryl iodides with sterically demanding substrates were also coupled to give the desired aryl thioethers in good to excellent yields. Copyright

Synthesis of CuO on mesoporous silica and its applications for coupling reactions of thiols with aryl iodides

Novel CuO on mesoporous silica is prepared under a convenient approach, and has been shown to be an efficient catalyst for cross-coupling reactions of thiols with aryl iodides with only 1.0-5.0 mol% catalyst loading.

Novel imidazole-based histamine H3 antagonists

A novel series of imidazole containing histamine H3 receptor ligands were investigated and found to be potent functional antagonists. After improving the stability of these molecules towards liver microsomes, these compounds were found to have

Iron-catalyzed S-arylation of thiols with aryl iodides

(Chemical Equation Presented) Strike while the iron is hot: An efficient iron-catalyzed protocol for the S-arylation of aromatic and heteroaromatic thiol derivatives has been developed, which involves an inexpensive catalyst system formed by combining FeCl3 and N,N′-dimethylethylenediamine at 135°C. This method avoids the use of expensive and/or air-sensitive ligands and provides in most cases the desired sulfide in high yields.

3-‘4-HETEROCYCLYL -1,2,3,-TRIAZOL-1-YL!-N-ARYL-BENZAMIDES AS INHIBITORS OF THE CYTOKINES PRODUCTION FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES

Disclosed compounds of formula (I), which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.