34555-37-8Relevant academic research and scientific papers
Facile Synthesis of γ-Ketonitriles in Water via C(sp2)–H Activation of Aromatic Aldehydes over Cu?g-C3N4 under Visible-Light
Bhardiya, Smita R.,Rai, Ankita,Rai, Vijai K.,Sheshma, Harendra,Singh, Manorama,Verma, Fooleswar
, p. 5841 - 5846 (2020/09/21)
A facile C(sp2)–H activation of aldehyde under visible-light conditions using Cu?g-C3N4 as photocatalyst and water as solvent is reported. The envisaged method involves photocatalytic intermolecular Stetter reaction using
Copper-Catalyzed Decarboxylative Oxyalkylation of Alkynyl Carboxylic Acids: Synthesis of ?-Diketones and ?-Ketonitriles
Li, Yi,Shang, Jia-Qi,Wang, Xiang-Xiang,Xia, Wen-Jin,Yang, Tao,Xin, Yangchun,Li, Ya-Min
supporting information, p. 2227 - 2230 (2019/03/26)
A novel copper-catalyzed decarboxylative oxyalkylation of alkynyl carboxylic acids with ketones and alkylnitriles via direct C(sp3)-H bond functionalization to construct new C-C bonds and C-O double bonds was developed. This transformation is featured by wide functional group compatibility and the use of readily available reagents, thus affording a general approach to ?-diketones and ?-ketonitriles. A possible mechanism is proposed.
Unactivated C(sp3)-H Bond Functionalization of Alkyl Nitriles with Vinylarenes and Mechanistic Studies
Lan, Xing-Wang,Wang, Nai-Xing,Bai, Cui-Bing,Lan, Cui-Lan,Zhang, Tong,Chen, Shi-Lu,Xing, Yalan
supporting information, p. 5986 - 5989 (2016/12/09)
The first example of a metal-free unactivated C(sp3)-H bond functionalization of alkyl nitriles with terminal vinylarenes to provide γ-ketonitrile derivatives is described. This protocol features simple operations, a broad substrate scope, and atom and step economy. In addition, Cu-catalyzed C(sp3)-H bond functionalization of azodiisobutyronitrile (AIBN) and analogues with terminal vinylarenes to generate γ-ketonitriles was also studied. A preliminary free-radical pathway was confirmed by capturing an alkyl radical, and a conjugate system was found that can stabilize radical intermediates and be in favor of this transformation. Density functional theory (DFT) calculations also provide important evidence of the free-radical pathway.
A new method for the synthesis of γ-oxobutyronitriles via addition of aroyl chlorides to acrylonitrile promoted by samarium metal in DMF
Liu, Yongjun,Zhang, Yongmin
, p. 163 - 164 (2007/10/03)
Without any pretreatment or activator, metallic samarium in DMF promotes the addition of aroyl chlorides to acrylonitrile to form γ -oxobutyronitriles.
5-(3-Phenyl-3-oxo-propyl)-1H-tetrazole derivatives
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, (2008/06/13)
PCT No. PCT/EP98/04032 Sec. 371 Date Dec. 30, 1999 Sec. 102(e) Date Dec. 30, 1999 PCT Filed Jun. 25, 1998 PCT Pub. No. WO99/02506 PCT Pub. Date Jan. 21, 19995-(3-phenyl-3-oxo-propyl)-1H-tetrazole derivatives of formula (I) wherein each of R and R1, being
SUBSTITUTED THIO-SUBSTITUTED BENZYL-PROPIONYL-L-PROLINES
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, (2008/06/13)
This disclosure describes novel substituted ω-aroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.
6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents
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, (2008/06/13)
This disclosure describes novel substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines useful as hypotensive agents.
