34564-00-6

Upstream product

• 5619-07-8 methyl 2-amino-3-phenylpropanoate hydrochloride 
• 1402135-34-5 2-((1-methoxy-1-oxo-3-phenylpropan-2-yl)-carbamoyl)benzoic acid 

Downstream Products

• 1402135-42-5 C₃₉H₃₆N₂O₅ 
• 1402135-43-6 C₃₉H₃₄N₂O₆ 
• 1402135-44-7 C₃₃H₂₉N₃O₄ 
• 1402135-46-9 C₃₄H₃₂N₂O₆ 
• 1402135-47-0 C₃₉H₃₆N₂O₇S 
• 1402135-48-1 C₂₇H₂₆N₂O₆ 
• 1402135-49-2 C₃₂H₃₀N₂O₇S 
• 1402135-50-5 C₃₂H₃₀N₂O₅ 
• 1402135-51-6 C₂₅H₂₄N₂O₄ 
• 112408-17-0 2-((1-chloro-1-oxo-3-phenylpropan-2-yl)carbamoyl)benzoic acid 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS

Described herein are compounds and compositions for the amelioration of arthritis or joint injuries by inducing mesenchymal stem cells into chondrocytes.

Identification of novel 2-((1-(benzyl(2-hydroxy-2-phenylethyl)amino)-1-oxo- 3-phenylpropan-2-yl)carbamoyl)benzoic acid analogues as BMP-2 stimulators

The synthesis and SAR studies of 10 new chemical entities (NCEs) that have shown BMP-2 stimulation and osteoblast differentiation are reported. Among these, 2-((1-(benzyl(2-hydroxy-2-phenylethyl)amino)-1-oxo-3-phenylpropan-2-yl) carbamoyl)benzoic acid (11) was the most effective while its analogue 13 also showed good activity in inducing osteoblast BMP-2 production. Compound 11 induced osteoblast differentiation in vitro, and this effect was abrogated by a physiological BMP-2 inhibitor, noggin. It also exhibited dose dependent increase in nascent bone formation (2.16- and 3.12-fold more than the control at 1 and 5 mg/kg dose, respectively) at the fracture site in rats. At the maximum osteogenic concentration, compound 11 significantly inhibited osteoblastic proteosomal activity. This compound was safe, as it had no effect on BMP synthesis in cardiovascular tissue.