34564-38-0

Basic information

• Product Name: 1,3-Diacetoxy-2-bromo-2-nitropropane
• Synonyms: 1,3-Diacetoxy-2-bromo-2-nitropropane
• CAS NO: 34564-38-0
• Molecular Formula: C7H10 Br N O6
• Molecular Weight: 284.06
• Mol File: 34564-38-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-Diacetoxy-2-bromo-2-nitropropane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Diacetoxy-2-bromo-2-nitropropane(34564-38-0)
• EPA Substance Registry System: 1,3-Diacetoxy-2-bromo-2-nitropropane(34564-38-0)

Safety Data

• Hazardous Substances Data: 34564-38-0(Hazardous Substances Data)

Usage

Functional groups

Acetoxy, bromo, and nitro

Category

Organic compound

Usage

Reagent in organic synthesis

Applications

Synthesis of pharmaceutical compounds and production of fine chemicals

Hazardous nature

Considered a hazardous chemical

Handling and storage

Should be handled and stored with caution

Upstream product

• 52-51-7 2-bromo-2-nitro-1,3-propanediol 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 

Relevant articles and documents

Simultaneous in-cell derivatization pressurized liquid extraction for the determination of multiclass preservatives in leave-on cosmetics

An effective one-step sample preparation methodology for the determination of multiclass preservatives in cosmetics has been developed, applying, for the first time to this kind of matrix, pressurized liquid extraction (PLE) and a very simple, cheap, and fast derivatization procedure: acetylation with acetic anhydride and pyridine. A multifactorial experimental design has been used to evaluate and optimize the main experimental parameters potentially affecting the extraction process. In the final conditions the sample was mixed with Florisil as the dispersing sorbent and extracted with ethyl acetate for 15 min at 120 °C. One of the main goals of this work was to demonstrate the possibility of carrying out direct cosmetic preservative acetylation by simply adding the derivatization reagents into the PLE cell. The extract was then analyzed by GC/MS without any further cleanup or concentration step. The accuracy, precision, linearity, and detection limits (LODs) were evaluated to assess the performance of the proposed method. Quantitative recoveries were obtained, and relative standard deviation values were lower than 10% in all cases. The obtained LODs ranged from 0.000004% to 0.0001% (w/w), values far below the established restrictions in the European Cosmetics Regulation, making this multicomponent analytical method suitable for routine control. Finally, several cosmetic products such as moisturizing and antiwrinkle creams and lotions, hand creams, sunscreen and after-sun creams, baby lotions, and hair care products were analyzed. All the samples contained several of the target cosmetic ingredients, in some cases at quite high concentrations, although the actual European Cosmetics Regulation was fulfilled in all cases.