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345643-03-0

(S)-N-(phenylacetyl)-α-phenylglycinonitrile is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 345643-03-0 Structure

  • Basic information

    1. Product Name: (S)-N-(phenylacetyl)-α-phenylglycinonitrile
    2. Synonyms: (S)-N-(phenylacetyl)-α-phenylglycinonitrile
    3. CAS NO:345643-03-0
    4. Molecular Formula:
    5. Molecular Weight: 250.3
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 345643-03-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (S)-N-(phenylacetyl)-α-phenylglycinonitrile(CAS DataBase Reference)
    10. NIST Chemistry Reference: (S)-N-(phenylacetyl)-α-phenylglycinonitrile(345643-03-0)
    11. EPA Substance Registry System: (S)-N-(phenylacetyl)-α-phenylglycinonitrile(345643-03-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 345643-03-0(Hazardous Substances Data)

345643-03-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 345643-03-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,5,6,4 and 3 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 345643-03:
(8*3)+(7*4)+(6*5)+(5*6)+(4*4)+(3*3)+(2*0)+(1*3)=140
140 % 10 = 0
So 345643-03-0 is a valid CAS Registry Number.

345643-03-0Relevant articles and documents

Enantioselective acylation of α-aminonitriles catalysed by Candida antarctica lipase. An unexpected turnover-related racemisation

Lopez-Serrano,Jongejan,Van Rantwijk,Sheldon

, p. 219 - 228 (2001)

Candida antarctica lipase B (Novozyme 435) catalysed the enantioselective acylation of 2-amino-2-phenylacetonitrile 1 with ethyl phenylacetate affording a near enantiopure product in 47% yield. Acylation of 1 and 2-amino-4-phenylbutyronitrile with ethyl a

Resolution of (RS)-phenylglycinonitrile by penicillin acylase-catalyzed acylation in aqueous medium

Chilov, Ghermes G.,Moody, Harold M.,Boesten, Wilhelmus H. J.,Svedas, Vytas K.

, p. 2613 - 2617 (2007/10/03)

A new strategy for the biocatalytic resolution of (R,S)-phenylglycinonitrile, a crucial intermediate in the antibiotic industry, has been developed. While former techniques exploit nitrilases or combinations of nitrile hydratases and amidases, manipulating with nitrile functionality, the current approach is based on a highly efficient and enantioselective acylation of the α-amino group with phenylacetic acid catalyzed by a well known enzyme, penicillin acylase from E. coli, in slightly acidic aqueous medium. It is shown that since the condensation product is poorly soluble, removal of (S)-phenylglycinonitrile from the reaction sphere is almost complete and irreversible, favoring kinetics of the process and making high conversion possible. The proposed approach is characterized by high space-time yield and extends the scope of enzymatic synthesis in aqueous medium.

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