345666-30-0Relevant academic research and scientific papers
Structure-activity relationships of novel HIV-1 protease inhibitors containing the 3-amino-2-chlorobenzoyl-allophenylnorstatine structure
Mimoto, Tsutomu,Nojima, Satoshi,Terashima, Keisuke,Takaku, Haruo,Shintani, Makoto,Hayashi, Hideya
, p. 1299 - 1308 (2008/09/19)
A series of peptidomimetic human immunodeficiency virus (HIV) protease inhibitors containing substituted allophenylnorstatine (Apns: (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid) were designed and synthesized. From the structure-activity relationship of this series of compounds, SM-309515 was found to have potent antiviral activity against wild-type and resistant HIV-1s and to possess a desirable pharmacokinetic profile in dogs.
