34577-34-9

Upstream product

• 529-20-4 2-methylphenyl aldehyde 
• 57132-25-9 4-(2-methylphenyl)butan-2-one 
• 75-16-1 methylmagnesium bromide 
• 16927-82-5 4-o-tolyl-3-buten-2-one 

Downstream Products

• 40650-33-7 1-(3-chloro-3-methylbutyl)-2-methylbenzene 
• 16204-72-1 2,3-dihydro-1,1,4-trimethyl-1H-indene 
• 34586-22-6 4-Nitro-benzenecarboperoxoic acid 1,1-dimethyl-3-o-tolyl-propyl ester 

Relevant academic research and scientific papers

8-Hydroxyquinolin-2(1H)-one analogues as potential β2-agonists: Design, synthesis and activity study

β2-Agonists that bind to plasmalemmal β2-adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their β2-agonistic activities with a cellular cAMP assay. Compounds B05 and C08 were identified as potent (EC50 2-agonists among the compounds tested. They behaved as partial β2-agonists in non-overexpressed HEK293 cells, and possessed rapid smooth muscle relaxant actions and long duration of action in isolated guinea pig tracheal strip preparations. In summary, B05 and C08 are β2-agonists with potential applicability in chronic respiratory diseases.