3458-56-8 Usage
Chemical structure
An imidazo[1,2-a]pyrimidine derivative
Functional groups
Phenyl ring
Methylsulfonyl group attached to the para position of the phenyl ring
Biological activities
Enzyme inhibition: Studied as an inhibitor of certain enzymes
Potential therapeutic applications: Investigated for its potential in treating various diseases
Research significance
Promising candidate for further research and development in medicinal chemistry
Check Digit Verification of cas no
The CAS Registry Mumber 3458-56-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,4,5 and 8 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 3458-56:
(6*3)+(5*4)+(4*5)+(3*8)+(2*5)+(1*6)=98
98 % 10 = 8
So 3458-56-8 is a valid CAS Registry Number.
InChI:InChI=1/C13H11N3O2S/c1-19(17,18)11-5-3-10(4-6-11)12-9-16-8-2-7-14-13(16)15-12/h2-9H,1H3
3458-56-8Relevant articles and documents
CuI-catalyzed aerobic oxidative α-aminaton cyclization of ketones to access aryl or alkenyl-substituted imidazoheterocycles
Zhang, Yuhong,Zhang, Yuanfei,Chen, Zhengkai,Wu, Wenliang,Su, Weiping
supporting information, p. 12494 - 12504 (2014/01/17)
CuI-catalyzed aerobic oxidative synthesis of imidazoheterocycles has been achieved. Four hydrogen atoms were removed in one step. This protocol was compatible with a broad range of functional groups, and it has been also successfully extended to unsaturated ketones, bringing about the formation of alkenyl-substituted imidazoheterocycles, which were difficult to prepare by previous means. Preliminary mechanistic studies indicated that this reaction was most likely to proceed through a catalytic Ortoleva-King reaction. By using this method, the marketed drug Zolimidine could be prepared with 90% yield on a gram scale from commercially available materials.
