34582-07-5Relevant academic research and scientific papers
Evaluation of adenine as scaffold for the development of novel P2X3 receptor antagonists
Lambertucci, Catia,Sundukova, Mayya,Kachare, Dhuldeo D.,Panmand, Deepak S.,Dal Ben, Diego,Buccioni, Michela,Marucci, Gabriella,Marchenkova, Anna,Thomas, Ajiroghene,Nistri, Andrea,Cristalli, Gloria,Volpini, Rosaria
, p. 41 - 50 (2013/10/01)
Ligands that selectively block P2X3 receptors localized on nociceptive sensory fibres may be useful for the treatment of chronic pain conditions including neuropathic pain, migraine, and inflammatory pain. With the aim at exploring the suitability of aden
Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases
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Page/Page column 79-80, (2010/11/26)
Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
Diaminopyrimidines as P2X3 and P2X2/3 antagonists
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Page/Page column 83, (2010/02/14)
Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
