34583-99-8

Usage

Uses

Used in Pharmaceutical Synthesis:
Cyclohexanecarboxylic acid, 3-amino-, trans(9CI) serves as a key building block in the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows for the creation of diverse molecules with potential therapeutic applications.
Used in Research and Development:
Cyclohexanecarboxylic acid, 3-amino-, trans(9CI) is utilized in research and development to explore its potential biological and pharmacological properties. The presence of the amino group and its trans configuration may contribute to novel interactions with biological targets, offering opportunities for the discovery of new drugs and therapeutic agents.
Used in Chemical Synthesis:
Cyclohexanecarboxylic acid, 3-amino-, trans(9CI) is employed in chemical synthesis processes to create a wide range of organic compounds. Its versatile structure allows for the development of new materials with various applications in different industries.
Used in Drug Design:
Cyclohexanecarboxylic acid, 3-amino-, trans(9CI)'s unique structure makes it a valuable tool in drug design, where it can be used to create new molecules with specific biological activities. Its potential as a building block for pharmaceuticals highlights its importance in the development of innovative treatments for various diseases and conditions.

Upstream product

• 99-05-8 meta-aminobenzoic acid 
• 123-51-3 i-Amyl alcohol 
• 334932-13-7 3-[(tert-butoxycarbonyl)amino]cyclo-hexanecarboxylic acid 
• 116724-13-1 trans rac-cyclohexyl 1,3-dicarboxylic acid 
• 4720-83-6 6-oxabicyclo[3.2.1]oct-3-en-7-one 

Downstream Products

• 53084-60-9 ethyl 3-aminocyclohexanecarboxylate 
• 334932-13-7 3-[(tert-butoxycarbonyl)amino]cyclo-hexanecarboxylic acid 
• 388630-74-8 3-aminocyclohexanecarboxylic acid dimethyl amide 
• 388630-67-9 (3-dimethylcarbamoyl-cyclohexyl)-carbamic acid tert-butyl ester 
• 388630-88-4 2-[1-(3-dimethylcarbamoyl-cyclohexylcarbamoyl)-cyclopentylmethyl]-pentanoic acid tert-butyl ester 
• 21531-44-2 (+/-)-cis-3-hydroxycyclohexanecarboxylic acid 
• 712313-64-9 methyl 3-aminocyclohexanecarboxylate hydrochloride 
• 925921-14-8 3-hydroxymethyl-1-cyclohexylamine 
• 87091-29-0 methyl 3-aminocyclohexanecarboxylate 
• 244156-66-9 3-[3-(4-trifluoromethyl-phenyl)-ureido]-benzoic acid 
• 1035324-95-8 3-(3,5-dimethoxybenzamido)cyclohexanecarboxylic acid 
• 1142087-64-6 3-{[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino}cyclohexanecarboxylic acid 
• 1001010-72-5 3-(4-oxo-2-thioxo-thiazolidin-3-yl)-cyclohexanecarboxylic acid 
• 218772-92-0 (±)-cis-3-((tert-butoxycarbonyl)amino)cyclohexanecarboxylic acid 

Relevant academic research and scientific papers

An improved synthesis of (1R,3S)-3-[(tert-butoxycarbonyl)amino] cyclohexanecarboxylic acid

An improved synthesis of (1R,3S)-3-[(tert-butoxycarbonyl)amino] cyclohexanecarboxylic acid from 3-aminobenzoic acid is described utilising milder and more selective conditions. Both a classical salt resolution and an enzymatic approach have been shown to give the desired compound in high selectivity.

Self-assembled peptide tubelets with 7 A pores

Here we report the preparation and structural characteristics of self-assembling peptide tubelets composed of 32-membered rings formed of alternating cx-amino acids and cis-3-aminocyclohexanecarboxylic acids. The tubelets possess a partial hydrophobic cor

New cyclic peptide assemblies with hydrophobic cavities: The structural and thermodynamic basis of a new class of peptide nanotubes

A new class of self-assembling peptides based on cyclic peptides made of alternating 3-aminocyclohexanecarboxylic acid (γ-Acc) and α-amino acids is described. The studied cylindrical assemblies are models for a new class of self-assembling peptide nanotub

Substituted pyrroles suitable for continuous infusion

Disclosed are novel substituted pyrroles having the formula These compounds and their pharmaceutically acceptable salts are suitable for administration to patients as continuous infusion solution and are useful in the treatment and/or control of cell prol

2-aminopyridine derivatives and combinatorial libraries thereof

The present invention relates to novel 2-aminopyridine derivative compounds of the following formula: wherein R1to R5have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing 2-aminopyridine derivative compounds.

Diaminopropionic acid derivatives

A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.

Opioid deltorphin C analogues containing cis- or trans-2- or 3- or 4- aminocyclohexanecarboxylic acid residues

The solid phase synthesis, based on the Fmoc chemical protocol, was used to prepare ten deltorphin C (Del-C; H-Tyr-D-Ala-Phe-Asp-Val-Val-Gly-NH2) analogues containing cis- and trans- 2 or 3- or 4- aminocyclohexanecarboxylic acid (ACCA) residues at position 2, ACCA-peptides showed high resistance to degradation by plasma or brain enzymes, negligible affinity for the κ- binding site and modest δ- and/or μ-receptor affinities. Both [cis-3- ACCA2]Del-C analogues and one trans isomer are the only deltorphin analogues of this series exhibiting an appreciable δ-affinity and selectivity. These data suggest that the presence of a conformationally constrained ACCA residue in position 2 of the 'message' sequence of deltorphin C is slightly tolerated.

A mild and facile reduction of azides to amines by N,N-dimethylhydrazine and catalytic ferric chloride

Reaction of a variety of azido compounds with N,N-dimethylhydrazine in the presence of a catalytic amount of ferric chloride hexahydrate in methanol results in excellent yields of the corresponding amino compounds. This reductive system is compatible with a wide assortment of functional groups and has also been extended towards the synthesis of pyrrolo[2,1-c][1,4]benzodiazepine antibiotics.

Palladium(0)-Catalyzed Azidation of Allyl Esters. Selective Synthesis of Allyl Azides, Primary Allylamines, and Related Compounds

Palladium(0)-catalyzed reaction of allyl esters such as phosphates, carbonates, and carboxylates with sodium azide gives allyl azides.The azidation proceeds with retention of configuration at the allylic carbon.Optically active (R)-(E)-(+)-4-phenyl-3-buten-2-yl azide (19) is obtained from (R)-(E)-(+)-4-phenyl-3-buten-2-yl acetate (18) stereoselectively.Sequential substitution of (Z)-4-acetoxy-2-buten-1-yl diethyl phosphate (24) with nucleophiles and subsequently azide ion gives (E)-4-substituted-2-buten-1-yl azides 27.The reaction of allyl azides with triphenylphosphine gives iminotriphenylphosphoranes, which are versatile synthetic intermediates of primary allylamines, N-allylamines, and N-allylamides.Treatment of allyl azides with triphenylphosphine and subsequently with aqueous ammonium solution gives primary allylamines.Other synthetic applications of allyl azides are also described.

Cyclohexyl and phenyl substituted enkephalins

The invention discloses cyclohexyl and phenyl substituted enkephalin derivatives of the formula: STR1 Where R1, R2, R4, and R8 is hydrogen or alkyl of R3 is alkylthioalkyl or alkylsulfinylalkyl, X is: