345898-27-3Relevant academic research and scientific papers
Total synthesis of the novel spider toxin NPTX-594 from Nephila madagascariencis
Wakamiya, Tateaki,Yamamoto, Akinori,Kawaguchi, Keita,Kinoshita, Tomohiko,Yamaguchi, Yoshihiro,Itagaki, Yasuhiro,Naoki, Hideo,Nakajima, Terumi
, p. 1743 - 1749 (2007/10/03)
A novel spider toxin, NPTX-594, comprised of four constituents: i.e., 2,4-dihydroxyphenylacetic acid (Dhpa), asparagine, 4,8-diaza-1,12-dodecanediamine (Dada), and lysine, was chemically synthesized. The synthetic compound was completely identical with the natural product as regards 1H NMR and mass spectra. The structure of NPTX-594 was thus determined synthetically to be N12-(Dhpa-Asn)-N1-Lys-Dada, as proposed by spectrometric elucidation.
