34591-70-3Relevant academic research and scientific papers
Novel 3-phenylpiperidine-4-carboxamides as highly potent and orally long-acting neurokinin-1 receptor antagonists with reduced CYP3A induction
Shirai, Junya,Sugiyama, Hideyuki,Morimoto, Shinji,Maezaki, Hironobu,Yamamoto, Yasuharu,Okanishi, Satoshi,Kamo, Izumi,Matsumoto, Shiho,Ishigami, Keiko,Inatomi, Nobuhiro,Imanishi, Akio,Kawamoto, Makiko,Tarui, Naoki,Hashimoto, Tadatoshi,Ikeura, Yoshinori
experimental part, p. 962 - 977 (2012/03/26)
The synthesis and biological evaluation of a series of novel 3-phenylpiperidine-4-carboxamide derivatives are described. These compounds are generated by hybridization of the substructures from two types of tachykinin NK1 receptor antagonists.
Tricyclic indanyls as integrin inhibitors
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Page/Page column 15-16, (2010/02/10)
The present invention is directed to substituted indanyl compounds of Formula (I): Useful for treating integrin-mediated disorders such as, but not limited to unstable angina, thromboemboic disorders, osteoporosis, growth and metastasis of malignant tumors, diabetic retinopathy, arthritis, viral disease and surgical adhesions.
