860472-89-5Relevant academic research and scientific papers
Novel 3-phenylpiperidine-4-carboxamides as highly potent and orally long-acting neurokinin-1 receptor antagonists with reduced CYP3A induction
Shirai, Junya,Sugiyama, Hideyuki,Morimoto, Shinji,Maezaki, Hironobu,Yamamoto, Yasuharu,Okanishi, Satoshi,Kamo, Izumi,Matsumoto, Shiho,Ishigami, Keiko,Inatomi, Nobuhiro,Imanishi, Akio,Kawamoto, Makiko,Tarui, Naoki,Hashimoto, Tadatoshi,Ikeura, Yoshinori
, p. 962 - 977 (2012/03/26)
The synthesis and biological evaluation of a series of novel 3-phenylpiperidine-4-carboxamide derivatives are described. These compounds are generated by hybridization of the substructures from two types of tachykinin NK1 receptor antagonists.
