345915-64-2

Basic information

• Product Name: 4-(IODO-PHENYL)-METHANE SULFONYL CHLORIDE
• Synonyms: 4-(IODO-PHENYL)-METHANE SULFONYL CHLORIDE;(4-Iodophenyl)methanesulphonyl chloride
• CAS NO: 345915-64-2
• Molecular Formula: C₇H₆ClIO₂S
• Molecular Weight: 316.54
• Mol File: 345915-64-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(IODO-PHENYL)-METHANE SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(IODO-PHENYL)-METHANE SULFONYL CHLORIDE(345915-64-2)
• EPA Substance Registry System: 4-(IODO-PHENYL)-METHANE SULFONYL CHLORIDE(345915-64-2)

Safety Data

• Hazardous Substances Data: 345915-64-2(Hazardous Substances Data)

Downstream Products

• 803727-90-4 N,N-bis(2,4-dimethoxybenzyl)-1-(4-iodophenyl)methanesulfonamide 
• 1238832-31-9 5-(4-acetoxyphenyl)-3-benzyl-2-bis(4-iodobenzylsulfonyl)aminopyrazine 
• 916726-85-7 (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(difluoro((neopentyloxy)sulfonyl)methyl)phenyl)propanoic acid 
• 803727-99-3 N,N-bis(2,4-dimethoxybenzyl)-1,1-difluoro-1-(4-iodophenyl)methanesulfonamide 
• 345915-66-4 2,2,2-trichloroethyl (4-iodo-phenyl)methanesulfonate 

Relevant articles and documents

Synthesis and evaluation of peptidic thrombin inhibitors bearing acid-stable sulfotyrosine analogues

Tyrosine sulfation is an important post-translational modification of peptides and proteins which underpins and modulates many protein-protein interactions. In order to overcome the inherent instability of the native modification, we report the synthesis of two sulfonate analogues and their incorporation into two thrombin-inhibiting sulfopeptides. The effective mimicry of these sulfonate analogues for native sulfotyrosine was validated in the context of their thrombin inhibitory activity and binding mode, as determined by X-ray crystallography.

Synthesis of Protected L-4-[Sulfono(difluoromethyl)]phenylalanine and Its Incorporation into a Peptide

matrix presented A protected form of L-4-[sulfono(difluoromethyl)]phenylalanine (F2Smp), a novel non-hydrolyzable phospho- and sulfotyrosine mimetic, was synthesized via electrophilic fluorination of a benzylic sulfonate followed by a Pd-cataly