34595-24-9

Usage

Chemical compound

1,1'-(2-Chlorobenzylidene)bispiperidine

Usage

Cough suppressant and antitussive medication

Mechanism of action

Acts on the cough center in the brain to suppress the urge to cough

Classification

Opioid antitussive

Availability

Over-the-counter cough syrups and cold medications

Physical appearance

White to off-white crystalline powder

Solubility

Soluble in water and alcohol

Sedative effects

Known for its sedative effects

Caution

Should be used with caution, especially when operating heavy machinery or driving

Effectiveness

Widely used and effective for the relief of cough symptoms

Upstream product

• 110-89-4 piperidine 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 110-89-4 piperidine 
• 59507-48-1 1-(2-chlorobenzyl)piperidine 
• 1409957-23-8 1-(1-(2-chlorophenyl)-2,2-difluoro-2-(phenylsulfonyl)ethyl)piperidine 

Relevant academic research and scientific papers

Preparation of aminals in water

Aminals, which are used as protecting groups in syntheses and are part of many biologically active compounds, are normally prepared from aldehydes and diamines under conditions that remove water in order to shift the equilibrium to the side of the aminal.

Formic Acid Reduction. XXVIII. Kinetic Studies on the Formic Acid Reduction of 1,1'-Benzylidenedipiperidine

The formic acid reduction of 1,1'-benzylidenedipiperidine (1) was kinetically investigated by the carbon dioxide trapping method.Rate data gave the rate equation, v=kobs.The initial mono- and diprotonation of 1 occur in equilibrium, and monoprotonated form is proposed to be an intermediate for the reduction to 1-benzylpiperidine.The isotope effect value (2.69) and the negative ρ substituent effect (similar to that of the formic acid reduction of N-benzylideneaniline) suggest that the reduction of 1 involves the same intermediate step of decarboxylation of the formic acid ester of the α-amino alcohol.