345963-96-4

Usage

Uses

Used in Organic Synthesis:
(2-fluoro-4-iodophenyl)-acetic acid serves as a valuable component in organic synthesis, contributing to the creation of a wide array of chemical compounds for different applications.
Used in Pharmaceutical Research:
In pharmaceutical research, (2-fluoro-4-iodophenyl)-acetic acid is used as a key intermediate. Its unique structure allows scientists to explore its potential in developing new drugs and enhancing existing ones.
Used in Drug Development:
(2-fluoro-4-iodophenyl)-acetic acid is utilized in the development of new drugs due to its potential pharmacological properties. It aids in the design and synthesis of novel therapeutic agents.
Used as a Chemical Intermediate in Pharmaceutical Production:
(2-fluoro-4-iodophenyl)-acetic acid acts as a chemical intermediate in the production of various pharmaceuticals, playing a crucial role in the synthesis of a range of medications.
Used in Agrochemical Production:
(2-fluoro-4-iodophenyl)-acetic acid also finds application in the agrochemical industry, where it serves as an intermediate in the synthesis of chemicals used in agriculture.
Used in Medicinal Chemistry for Therapy Development:
In the field of medicinal chemistry, (2-fluoro-4-iodophenyl)-acetic acid is employed for the development of new therapies and treatments, potentially leading to advancements in medical care.

Upstream product

• 85510-81-2 2-fluoro-4-iodo-benzyl bromide 
• 39998-81-7 2-fluoro-4-iodotoluene 
• 345963-95-3 (2-fluoro-4-iodophenyl)-acetonitrile 
• 64-17-5 ethanol 

Downstream Products

• 856250-89-0 (2-fluoro-4-iodo-phenyl)-acetic acid 2-trimethylsilanyl-ethyl ester 
• 856250-88-9 (2-fluoro-4-iodo-phenyl)-acetic acid acetoxymethyl ester 
• 345963-98-6 2-fluoro-4-iodo phenyl acetic acid methyl ester 
• 503614-64-0 methyl [2-fluoro-4-(2-oxo-1(2H)-pyridinyl)-phenyl]acetate 
• 503613-32-9 methyl 2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-oxopropanoate 
• 1117747-30-4 methyl 3-[1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-oxopropanoate 
• 503614-66-2 2-fluoro-5-[5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzonitrile 
• 503615-25-6 1-(4-{2-[1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-oxoethyl}-3-fluorophenyl)-2(1H)-pyridinone trifluoroacetate 
• 1117749-58-2 methyl 3-[3-cyano-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]-2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-oxopropanoate 
• 503614-73-1 5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-1-(4-methoxyphenyl)-1H-pyrazole-3-carbonitrile 
• 503613-35-2 5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide 
• 1110668-44-4 C₁₄H₂₀FIO₂Si 
• 345963-97-5 2-fluoro-4-iodo phenyl acetic acid ethyl ester 

Relevant academic research and scientific papers

LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS

The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4??I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

Structure-activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors

Efforts to further optimize the clinical candidate razaxaban have led to a new series of pyrazole-based factor Xa (fXa) inhibitors. Designed to prevent the potential formation of primary aniline metabolites in vivo, the nitrogen of the carboxamido linker

Lactam-containing compounds and derivatives thereof as factor Xa inhibitors

The present application describes lactam-containing compounds and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 2 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI

Novel compounds having the Formulas 1 through 8, wherein the symbols have the meaning defined in the specification, and certain previously known compounds have been discovered to act as inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. The compound can also be used in co-treatment with retinoids.

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.