503613-35-2

Upstream product

• 1117749-58-2 methyl 3-[3-cyano-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]-2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-oxopropanoate 
• 503614-71-9 3-cyano-1-(4-methoxyphenyl)-1H-pyrazole-5-carboxylic acid 
• 503614-70-8 5-(2-furyl)-1-(4-methoxyphenyl)-1H-pyrazole-3-carbonitrile 
• 503614-69-5 5-(2-furyl)-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide 
• 503614-64-0 methyl [2-fluoro-4-(2-oxo-1(2H)-pyridinyl)-phenyl]acetate 
• 345963-98-6 2-fluoro-4-iodo phenyl acetic acid methyl ester 
• 345963-96-4 (2-fluoro-4-iodophenyl)-acetic acid 
• 345963-95-3 (2-fluoro-4-iodophenyl)-acetonitrile 
• 85510-81-2 2-fluoro-4-iodo-benzyl bromide 
• 39998-81-7 2-fluoro-4-iodotoluene 
• 503614-44-6 lithium 1-tert-butoxy-4-(2-furyl)-1,4-dioxo-2-buten-2-olate 
• 503614-73-1 5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-1-(4-methoxyphenyl)-1H-pyrazole-3-carbonitrile 
• 67-56-1 methanol 

Relevant academic research and scientific papers

LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS

The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4??I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

Structure-activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors

Efforts to further optimize the clinical candidate razaxaban have led to a new series of pyrazole-based factor Xa (fXa) inhibitors. Designed to prevent the potential formation of primary aniline metabolites in vivo, the nitrogen of the carboxamido linker

Lactam-containing compounds and derivatives thereof as factor Xa inhibitors

The present application describes lactam-containing compounds and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.