34605-45-3

Basic information

• Product Name: (R)-(-)-N-(P-Tolylsulphonyl)glutamic acide
• Synonyms: (R)-(-)-N-(P-Tolylsulphonyl)glutamic acide
• CAS NO: 34605-45-3
• Molecular Formula: C₁₂H₁₅NO₆S
• Molecular Weight: 301.3156
• Mol File: 34605-45-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-(-)-N-(P-Tolylsulphonyl)glutamic acide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-N-(P-Tolylsulphonyl)glutamic acide(34605-45-3)
• EPA Substance Registry System: (R)-(-)-N-(P-Tolylsulphonyl)glutamic acide(34605-45-3)

Safety Data

• Hazardous Substances Data: 34605-45-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-(-)-N-(P-Tolylsulphonyl)glutamic acid is used as a synthetic intermediate for the development of naphthalene-N-sulfonyl-D-glutamate derivatives. These derivatives are known as MurD inhibitors, which play a crucial role in the inhibition of bacterial cell wall synthesis. By targeting this process, these inhibitors can potentially be used to combat bacterial infections, making (R)-(-)-N-(P-Tolylsulphonyl)glutamic acid a valuable component in the development of new antibiotics.

Upstream product

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Downstream Products

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Relevant articles and documents

Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme

Mur ligases have essential roles in the biosynthesis of peptidoglycan, and they represent attractive targets for the design of novel antibacterials. MurD (UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase) is the second enzyme in the series of Mur ligases, and it catalyzes the addition of D-glutamic acid (D-Glu) to the cytoplasmic intermediate UDP-N-acetylmuramoyl-L-alanine (UMA). Because of the high binding affinity of D-Glu toward MurD, we synthesized and biochemically evaluated a series of N-substituted D-Glu derivatives as potential inhibitors of MurD from E. coli, which allowed us to explore the structure-activity relationships. The substituted naphthalene-N-sulfonyl-D-Glu inhibitors, which were synthesized as potential transitionstate analogues, displayed IC50 values ranging from 80 to 600 μM. In addition, the high-resolution crystal structures of MurD in complex with four novel inhibitors revealed details of the binding mode of the inhibitors within the active site of MurD. Structure-activity relationships and cocrystal structures constitute an excellent starting point for further development of novel MurD inhibitors of this structural class.

PROCESS FOR PREPARING OPTICALLY ACTIVE CETIRIZINE OR ITS SALT

Provided are a process for preparing optically active cetirizine or its salt from racemic cetirizine or its salt using glutamate of 2-[2-[4-[(4-chlorphenyl)phenylmethyl]-1-piperazinyl] ethoxy]acetic ester and the glutamate of 2-[2-[4-[(4-chlorophenyl)phen