34616-35-8Relevant academic research and scientific papers
Stereoselectivity of the benzannulation reaction: Efficient central-to-axial chirality transfer
Vorogushin, Andrei V.,Wulff, William D.,Hansen, Hans-Juergen
, p. 6512 - 6513 (2002)
High diastereoselectivity is observed in the preparation of configurationally stable allocolchicinoids 5 from Fischer carbene complexes 4 and 1-pentyne. The analogous reaction of complexes 8 gives 9 with moderate diastereoselectivity for the opposite atro
Fully Regiocontrolled Synthesis of Deacetamidoisocolchicine: Formal Total Synthesis of Colchicine
Banwell, Martin G.,Lambert, John N.,Corbett, Madeline,Greenwood, Richard J.,Gulbis, Jacqueline M.,Mackay, Maureen F.
, p. 1415 - 1426 (2007/10/02)
A 19-step synthesis of deacetamidoisocolchicine 4 has been developed starting from commercially available benzaldehyde 10.Key elements of the strategy used include Robinson annulation of the benzosuberone 15 to produce the tricyclic enone 18 and elaborati
