34632-71-8

Usage

InChI:InChI=1/C9H8N4O2/c10-13-9(15)7-11-6-4-2-1-3-5(6)8(14)12-7/h1-4H,10H2,(H,13,15)(H,11,12,14)

Upstream product

• 29113-33-5 ethyl 4-oxo-3,4-dihydro-2-quinazolinecarboxylate 
• 28144-70-9 anthranilic acid amide 

Downstream Products

• 129302-08-5 4-Oxo-3,4-dihydro-quinazoline-2-carboxylic acid [1-p-tolyl-meth-(E)-ylidene]-hydrazide 
• 129302-09-6 4-Oxo-3,4-dihydro-quinazoline-2-carboxylic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 129302-11-0 4-Oxo-3,4-dihydro-quinazoline-2-carboxylic acid [1-(3-nitro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 129302-10-9 4-Oxo-3,4-dihydro-quinazoline-2-carboxylic acid [1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 129302-07-4 2-benzylidenehydrazinocarbonylquinazolin-4-(3H)-one 
• 129302-00-7 2-(4'-methoxybenzylidene)hydrazinocarbonylquinazolin-4-(3H)-one 
• 153776-85-3 C₂₃H₁₈N₆O₄ 
• 129320-52-1 4-Oxo-3,4-dihydro-quinazoline-2-carboxylic acid [1-(3-chloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 129302-02-9 2-(5-p-Tolyl-[1,3,4]oxadiazol-2-yl)-3H-quinazolin-4-one 
• 129301-99-1 2-[5-(4-Methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-3H-quinazolin-4-one 
• 113124-36-0 C₁₆H₁₄N₄O₄S 
• 129302-01-8 2-(5-Phenyl-[1,3,4]oxadiazol-2-yl)-3H-quinazolin-4-one 
• 129302-05-2 2-<4-(3H)-oxoquinazolin-2-yl>-5-(3-chlorophenyl)-1,3,4-oxadiazole 
• 129302-06-3 2-[5-(3-Nitro-phenyl)-[1,3,4]oxadiazol-2-yl]-3H-quinazolin-4-one 

Relevant academic research and scientific papers

Synthesis and Antimicrobial Activities of Novel Quinazolinone Acylhydrazone Derivatives Containing the Indole Moiety

A series of novel quinazolinone acylhydrazone derivatives containing the indole moiety were designed, synthesized, and evaluated for their inhibition activities against some important phytopathogens in vitro. Antibacterial experiments indicated that some compounds exhibited remarkable inhibition activities against tested bacteria. Especially, the EC50 values of 7a (EC50?=?55.13?μg/mL against Xoo, EC50?=?56.92?μg/mL against Rs) demonstrated the best antibacterial activities against Xoo and Rs than the other compounds, and the control agents Bismerthiazol (EC50?=?89.80?μg/mL against Xoo) and Thiodiazole copper (EC50?=?189.52?μg/mL against Rs), moreover, compound 7o (EC50?=?50.80?μg/mL) displayed the excellent activity against Xac than the control Bismerthiazol (EC50?=?56.92?μg/mL).

Synthesis and reactions of 2-ethoxycarbonyl-4(3H)-quinazolinone with nitrogen nucleophiles

2-Ethoxycarbonyl-4(3H)-quinazolinone (1) reacts with piperidine, methylamine and anthranilic acid to give the Mannich bases and 4H-3,1-benzoxazin-4-one derivatives.The behaviour of the latter towards some nitrogen nucleophilic has been described.Compound 1 also reacts with hydrazine and gives the corresponding hydrazide (8), the bahaviour of which towards aldehydes, ketones, and phenyl isocyanate has also been discussed.

Synthesis of Some New 4-Quinazolinone-2-carboxy Esters, 2-Carboxamides, 2-Carboxyhydrazides and Their Tosyl Derivatives Having Potential Biological Activity

Some new 2-carbethoxy-3,4-dihydro-4-oxoquinazolines (II) and their derivatives such as 2-carboxamides (III), carboxyhydrazides (IV) and the tosylhydrazides (V) have been synthesized.The antitubercular activity of IV has been determined.