34642-77-8

Basic information

• Product Name: Amoxicillin sodium
• Synonyms: (2S,5β)-6α-[[(R)-Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid sodium salt;Amoxycillin sodium salt;AMoxicillin SodiuM+Clavulanate PotassiuM(4:1);(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, sodium salt (1:1);Amoxycilline Sodium Sterile;(3as,6ar)-1,3-dibenzyltetrahydro-1h-thieno[3,4-d]imidazole-2,4-dione;AMOXICILLIN SODIUM;AMOXYCILLIN SODIUM
• CAS NO: 34642-77-8
• Molecular Formula: C₁₆H₁₈N₃O₅S*Na
• Molecular Weight: 388.39
• EINECS: 252-124-1
• Product Categories: Pharma;Inhibitors
• Mol File: 34642-77-8.mol

Chemical Properties

• Melting Point: 130℃
• Boiling Point: 743℃
• Flash Point: >110°(230°F)
• Appearance: A White CRYSTALLINE powder
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Very soluble in water, sparingly soluble in anhydrous ethanol, very slightly soluble in acetone.
• Water Solubility: Soluble in water.
• CAS DataBase Reference: Amoxicillin sodium(CAS DataBase Reference)
• NIST Chemistry Reference: Amoxicillin sodium(34642-77-8)
• EPA Substance Registry System: Amoxicillin sodium(34642-77-8)

Safety Data

• RTECS: XH8300000
• Hazardous Substances Data: 34642-77-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Amoxicillin sodium is used as an antibiotic for treating various bacterial infections. It is effective against both gram-positive and gram-negative bacteria, including Streptococcus, Staphylococcus, and Haemophilus species. Its broad-spectrum activity and high efficacy make it a popular choice for treating a variety of infections, such as respiratory, urinary, and skin infections.
Additionally, Amoxicillin sodium is often used in combination with clavulanate potassium and marketed as "Augmentin" for intravenous administration. This combination enhances the antibiotic's effectiveness by providing coverage against bacteria that produce beta-lactamase, an enzyme that can inactivate certain antibiotics.

InChI:InChI=1/C16H19N3O5S.Na/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);/q;+1/p-1

Upstream product

• 26787-78-0 amoxicillin 

Downstream Products

• 26787-78-0 amoxicillin 

Relevant articles and documents

IMPROVED PROCESS FOR PREPARING AMOXICILLIN SODIUM

An improved process for preparing sterile amoxicillin and an alkali metal salt thereof, wherein the said process involves the steps of: i) dissolving amoxicillin trihydrate in methyl acetate, methanol and triethylamine; ii) Passing the resulting solution through a series of filters iii) addition of mixture of sodium-2-ethylhexanoate, methyl acetate and methanol followed by addition of methyl acetate iv) crystallizing the product to obtain sterile amoxicillin sodium.

PROCESS FOR PREPARING GRANULATES COMPRISING AMOXICILLIN

A novel process for preparing a stable granulate, which comprises a mixture of amoxicillin trihydrate and amoxicillin sodium, by means of extrusion granulation of amoxicillin trihydrate with an aqueous solution of sodium hydroxide, sodium bicarbonate, sodium carbonate and mixture thereof or with an aqueous solution of sodium salt of (C1-8) organic acid as a sodium source to form a moist extruded mass, which is granulated through a sieve and dried the obtained granulate, is disclosed. Alternatively, a novel process for preparing a stable granulate comprising pure amoxicillin sodium may be obtained according to the above extrusion granulation process as well. In a further aspect the present invention relates to a novel stable granulate comprising the mixture of amoxicillin trihydrate and amoxicillin sodium or alternatively, to a novel stable granulate comprising pure amoxicillin sodium, whenever prepared according to the above decribed process. Novel granulate of the present invention may be used for reconstitution with water into aqueous suspension, for parenteral injection administration, for preparing solid dosage forms, e.g. tablets, dispersible tablets, capsules, chewable tablets, and is used for treating bacterial infections in humans or animals.