34646-03-2

Basic information

• Product Name: Benzenesulfonic acid, 4-methoxy-, 2-propynyl ester
• CAS NO: 34646-03-2
• Molecular Formula: C10H10O4S
• Molecular Weight: 226.253
• Mol File: 34646-03-2.mol

Chemical Properties

• CAS DataBase Reference: Benzenesulfonic acid, 4-methoxy-, 2-propynyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonic acid, 4-methoxy-, 2-propynyl ester(34646-03-2)
• EPA Substance Registry System: Benzenesulfonic acid, 4-methoxy-, 2-propynyl ester(34646-03-2)

Safety Data

• Hazardous Substances Data: 34646-03-2(Hazardous Substances Data)

Upstream product

• 107-19-7 propargyl alcohol 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 

Relevant articles and documents

A chemical labeling of N6-formyl adenosine (f6A) RNA

N6-methyl adenosine (m6A) is an eminent epigenetic mark in mRNAs that affects a broad range of biological functions in diverse species. However, the chemically inert methyl group prevents a direct labeling of this modification for subsequent detection and sequencing. Therefore, most current approaches for the labeling of m6A still have limitations of relying on the utilization of corresponding methyltransferases, which resulted in the lacking of efficiency. Here we present an approach which selectively alkylated the N6-formyl adenosine (f6A), the key intermediate during chemical oxidation of m6A, with an alkyne functionality that can be further labeled with click reactions. This covalent labeling approach will be able to facilitate in the affinity purification, detection and genome-wide profiling studies.